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Increased incidence of pregnancy complications in women who later develop scleroderma: a case control study

Overview of attention for article published in Arthritis Research & Therapy, November 2011
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Title
Increased incidence of pregnancy complications in women who later develop scleroderma: a case control study
Published in
Arthritis Research & Therapy, November 2011
DOI 10.1186/ar3510
Pubmed ID
Authors

Linda van Wyk, Jacolien van der Marel, Annemie JM Schuerwegh, Anne A Schouffoer, Alexandre E Voskuyl, Tom WJ Huizinga, Diana W Bianchi, Sicco A Scherjon

Abstract

Studies have shown that fetal progenitor cells persist in maternal blood or bone marrow for more than 30 years after delivery. Increased trafficking of fetal cells occurs during pregnancy complications, such as hypertension, preeclampsia, miscarriage and intra-uterine growth restriction (IUGR). Women with these pregnancy complications are significantly more often HLA-class II compatible with their spouses. Women who later develop scleroderma also give birth to an HLA-class II child more often. From these prior studies we hypothesized that preeclampsia and other pregnancy complications could be associated with increased levels of fetal cell trafficking, and later be involved in the development of scleroderma.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Canada 1 3%
Unknown 38 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 23%
Researcher 9 23%
Student > Master 5 13%
Student > Ph. D. Student 4 10%
Other 4 10%
Other 5 13%
Unknown 4 10%
Readers by discipline Count As %
Medicine and Dentistry 21 53%
Nursing and Health Professions 4 10%
Agricultural and Biological Sciences 4 10%
Biochemistry, Genetics and Molecular Biology 2 5%
Social Sciences 2 5%
Other 1 3%
Unknown 6 15%