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Neutrophil–lymphocyte ratio in patients with major depressive disorder undergoing no pharmacological therapy

Overview of attention for article published in Neuropsychiatric Disease and Treatment, August 2015
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Citations

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Title
Neutrophil–lymphocyte ratio in patients with major depressive disorder undergoing no pharmacological therapy
Published in
Neuropsychiatric Disease and Treatment, August 2015
DOI 10.2147/ndt.s89470
Pubmed ID
Authors

Abdullah Atli, Süleyman Demir, Mahmut Bulut, Aslıhan Okan İbiloğlu, Mehmet Güneş, Mehmet Kaya, Özlem Demirpençe, Aytekin Sır

Abstract

Studies attempting to clarify the relationship between major depressive disorder (MDD) and the immune system have been increasing in recent years. It was reported that increased production of the main proinflammatory cytokines, such as interleukin-1, interleukin-6, and tumor necrosis factor-alpha, and that of acute phase reactants may play a role in the etiopathogenesis of depression. Stress and depression were reported to increase leukocyte and neutrophil counts and to decrease lymphocyte count. Biological determinants affecting the diagnosis, therapy, and prognosis of depression are quite limited. Therefore, new etiological models are needed to explain the pathophysiology of depression. In recent years, neutrophil-lymphocyte ratio (NLR) was determined to be a good indicator of inflammatory status. There is no study in the literature investigating NLR in MDD. This study aims to examine the role of inflammation in the etiology of depression based on the NLR in MDD patients who are undergoing no pharmacological therapy. A total of 41 patients diagnosed with MDD, who received no antidepressant therapy within the past 1 month, were included in the study, which took place between January and March 2015. The control group consisted of 47 healthy subjects with no psychiatric disorders. A sociodemographic information form and a Beck Depression Scale were administered, and the blood was taken for biochemical analysis. Significant differences were identified in the NLR, neutrophil count, lymphocyte percentage, and leukocyte values of the patient group when compared with the control group (P<0.05). Our study is the first in which NLR was investigated in MDD. The findings of the study reveal that NLR tends to be higher in patients with MDD, and a high NLR value supports the view that inflammation is a critical factor in the etiology of MDD.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Turkey 1 <1%
Unknown 103 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 18%
Researcher 17 16%
Student > Master 16 15%
Student > Doctoral Student 10 10%
Student > Bachelor 9 9%
Other 14 13%
Unknown 19 18%
Readers by discipline Count As %
Medicine and Dentistry 35 34%
Psychology 9 9%
Neuroscience 9 9%
Agricultural and Biological Sciences 6 6%
Biochemistry, Genetics and Molecular Biology 5 5%
Other 14 13%
Unknown 26 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2015.
All research outputs
#8,769,152
of 14,535,828 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,280
of 2,442 outputs
Outputs of similar age
#117,406
of 240,020 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#86
of 110 outputs
Altmetric has tracked 14,535,828 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,442 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,020 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 110 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.