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Genetic determinants of anti-malarial acquired immunity in a large multi-centre study

Overview of attention for article published in Malaria Journal, August 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

twitter
12 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
10 Dimensions

Readers on

mendeley
56 Mendeley
citeulike
2 CiteULike
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Title
Genetic determinants of anti-malarial acquired immunity in a large multi-centre study
Published in
Malaria Journal, August 2015
DOI 10.1186/s12936-015-0833-x
Pubmed ID
Authors

Jennifer M G Shelton, Patrick Corran, Paul Risley, Nilupa Silva, Christina Hubbart, Anna Jeffreys, Kate Rowlands, Rachel Craik, Victoria Cornelius, Meike Hensmann, Sile Molloy, Nuno Sepulveda, Taane G Clark, Gavin Band, Geraldine M Clarke, Christopher C A Spencer, Angeliki Kerasidou, Susana Campino, Sarah Auburn, Adama Tall, Alioune Badara Ly, Odile Mercereau-Puijalon, Anavaj Sakuntabhai, Abdoulaye Djimdé, Boubacar Maiga, Ousmane Touré, Ogobara K Doumbo, Amagana Dolo, Marita Troye-Blomberg, Valentina D Mangano, Frederica Verra, David Modiano, Edith Bougouma, Sodiomon B Sirima, Muntaser Ibrahim, Ayman Hussain, Nahid Eid, Abier Elzein, Hiba Mohammed, Ahmed Elhassan, Ibrahim Elhassan, Thomas N Williams, Carolyne Ndila, Alexander Macharia, Kevin Marsh, Alphaxard Manjurano, Hugh Reyburn, Martha Lemnge, Deus Ishengoma, Richard Carter, Nadira Karunaweera, Deepika Fernando, Rajika Dewasurendra, Christopher J Drakeley, Eleanor M Riley, Dominic P Kwiatkowski, Kirk A Rockett

Abstract

Many studies report associations between human genetic factors and immunity to malaria but few have been reliably replicated. These studies are usually country-specific, use small sample sizes and are not directly comparable due to differences in methodologies. This study brings together samples and data collected from multiple sites across Africa and Asia to use standardized methods to look for consistent genetic effects on anti-malarial antibody levels. Sera, DNA samples and clinical data were collected from 13,299 individuals from ten sites in Senegal, Mali, Burkina Faso, Sudan, Kenya, Tanzania, and Sri Lanka using standardized methods. DNA was extracted and typed for 202 Single Nucleotide Polymorphisms with known associations to malaria or antibody production, and antibody levels to four clinical grade malarial antigens [AMA1, MSP1, MSP2, and (NANP)4] plus total IgE were measured by ELISA techniques. Regression models were used to investigate the associations of clinical and genetic factors with antibody levels. Malaria infection increased levels of antibodies to malaria antigens and, as expected, stable predictors of anti-malarial antibody levels included age, seasonality, location, and ethnicity. Correlations between antibodies to blood-stage antigens AMA1, MSP1 and MSP2 were higher between themselves than with antibodies to the (NANP)4 epitope of the pre-erythrocytic circumsporozoite protein, while there was little or no correlation with total IgE levels. Individuals with sickle cell trait had significantly lower antibody levels to all blood-stage antigens, and recessive homozygotes for CD36 (rs321198) had significantly lower anti-malarial antibody levels to MSP2. Although the most significant finding with a consistent effect across sites was for sickle cell trait, its effect is likely to be via reducing a microscopically positive parasitaemia rather than directly on antibody levels. However, this study does demonstrate a framework for the feasibility of combining data from sites with heterogeneous malaria transmission levels across Africa and Asia with which to explore genetic effects on anti-malarial immunity.

Twitter Demographics

The data shown below were collected from the profiles of 12 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Brazil 1 2%
Tanzania, United Republic of 1 2%
United States 1 2%
Sri Lanka 1 2%
Unknown 51 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 27%
Student > Ph. D. Student 11 20%
Student > Master 8 14%
Student > Bachelor 6 11%
Student > Postgraduate 4 7%
Other 12 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 27%
Medicine and Dentistry 12 21%
Biochemistry, Genetics and Molecular Biology 10 18%
Immunology and Microbiology 5 9%
Nursing and Health Professions 3 5%
Other 11 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 September 2015.
All research outputs
#1,735,131
of 12,079,889 outputs
Outputs from Malaria Journal
#489
of 3,528 outputs
Outputs of similar age
#42,834
of 239,445 outputs
Outputs of similar age from Malaria Journal
#11
of 131 outputs
Altmetric has tracked 12,079,889 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,528 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,445 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 131 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.