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Competitive suppression of dengue virus replication occurs in chikungunya and dengue co-infected Mexican infants

Overview of attention for article published in Parasites & Vectors, July 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (55th percentile)

Mentioned by

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5 tweeters

Citations

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6 Dimensions

Readers on

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43 Mendeley
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Title
Competitive suppression of dengue virus replication occurs in chikungunya and dengue co-infected Mexican infants
Published in
Parasites & Vectors, July 2018
DOI 10.1186/s13071-018-2942-1
Pubmed ID
Authors

Mussaret B Zaidi, Julio Garcia-Cordero, Ricardo Rivero-Gomez, Josselin Corzo-Gomez, María Elena González y Almeida, Raúl Bonilla-Moreno, José Bustos-Arriaga, Nicolás Villegas-Sepulveda, Leopoldo Flores-Romo, Leticia Cedillo-Barron

Abstract

Co-circulation of dengue virus (DENV) and chikungunya virus (CHIKV) is increasing worldwide but information on the viral dynamics and immune response to DENV-CHIKV co-infection, particularly in young infants, is scant. Blood samples were collected from 24 patients, aged 2 months to 82 years, during a CHIKV outbreak in Mexico. DENV and CHIKV were identified by RT-PCR; ELISA was used to detect IgM and IgG antibodies. CHIKV PCR products were cloned, sequenced and subjected to BLAST analysis. To address serological findings, HMEC-1 and Vero cells were inoculated with DENV-1, DENV-2 and CHIKV alone and in combination (DENV-2-CHIKV and DENV-1-CHIKV); viral titers were measured at 24, 48 and 72 h. Nine patients (38%) presented co-infection, of who eight were children. None of the patients presented severe illness. Sequence analysis showed that the circulating CHIKV virus belonged to the Asian lineage. Seroconversion to both viruses was only observed in the four patients five years or older, while the five infants under two years of age only seroconverted to CHIKV. Viral titers in the CHIKV mono-infected cells were greater than in the DENV-1 and DENV-2 mono-infected cells. Furthermore, we observed significantly increased CHIKV progeny and reduction of DENV progeny in the co-infected cells. In our population, DENV-CHIKV co-infection was not associated with increased clinical severity. Our in vitro assay findings strongly suggest that the lack of DENV IgG conversion in the co-infected infants is due to suppression of DENV replication by the Asian lineage CHIKV. The presence of maternal antibody and immature immune responses in the young infants may also play a role.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 43 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 19%
Student > Master 8 19%
Student > Ph. D. Student 5 12%
Other 4 9%
Student > Postgraduate 3 7%
Other 7 16%
Unknown 8 19%
Readers by discipline Count As %
Medicine and Dentistry 8 19%
Agricultural and Biological Sciences 5 12%
Nursing and Health Professions 4 9%
Biochemistry, Genetics and Molecular Biology 4 9%
Immunology and Microbiology 4 9%
Other 4 9%
Unknown 14 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2019.
All research outputs
#8,695,932
of 16,250,503 outputs
Outputs from Parasites & Vectors
#1,665
of 4,349 outputs
Outputs of similar age
#123,204
of 278,983 outputs
Outputs of similar age from Parasites & Vectors
#1
of 1 outputs
Altmetric has tracked 16,250,503 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,349 research outputs from this source. They receive a mean Attention Score of 4.8. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,983 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them