Chapter title |
The CRISPR/Cas9 System as a Tool to Engineer Chromosomal Translocation In Vivo
|
---|---|
Chapter number | 4 |
Book title |
Chromosome Translocation
|
Published in |
Advances in experimental medicine and biology, January 2018
|
DOI | 10.1007/978-981-13-0593-1_4 |
Pubmed ID | |
Book ISBNs |
978-9-81-130592-4, 978-9-81-130593-1
|
Authors |
Taek-Chin Cheong, Rafael B. Blasco, Roberto Chiarle, Cheong, Taek-Chin, Blasco, Rafael B., Chiarle, Roberto |
Abstract |
The CRISPR/Cas9 system has emerged as a powerful tool to edit the genome. Among many applications, the system generates the exciting possibility of engineering small and large portions of chromosomes to induce a variety of structural alterations such as deletions, inversions, insertions and inter-chromosomal translocations. Furthermore, the availability of viral vectors that express Cas9 has been critical to deliver the CRISPR/Cas9 system directly in vivo to induce chromosomal rearrangements. This review provides an overview of the state-of-the-art CRISPR/Cas9 technology to model a variety of rearrangements in vivo in animal models. |
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Medicine and Dentistry | 1 | 4% |
Other | 0 | 0% |
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