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Mitigation of impedance changes due to electroporation therapy using bursts of high-frequency bipolar pulses

Overview of attention for article published in BioMedical Engineering OnLine, January 2015
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  • Above-average Attention Score compared to outputs of the same age (59th percentile)

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1 Wikipedia page

Citations

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41 Mendeley
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Title
Mitigation of impedance changes due to electroporation therapy using bursts of high-frequency bipolar pulses
Published in
BioMedical Engineering OnLine, January 2015
DOI 10.1186/1475-925x-14-s3-s3
Pubmed ID
Authors

Suyashree P Bhonsle, Christopher B Arena, Daniel C Sweeney, Rafael V Davalos

Abstract

For electroporation-based therapies, accurate modeling of the electric field distribution within the target tissue is important for predicting the treatment volume. In response to conventional, unipolar pulses, the electrical impedance of a tissue varies as a function of the local electric field, leading to a redistribution of the field. These dynamic impedance changes, which depend on the tissue type and the applied electric field, need to be quantified a priori, making mathematical modeling complicated. Here, it is shown that the impedance changes during high-frequency, bipolar electroporation therapy are reduced, and the electric field distribution can be approximated using the analytical solution to Laplace's equation that is valid for a homogeneous medium of constant conductivity. Two methods were used to examine the agreement between the analytical solution to Laplace's equation and the electric fields generated by 100 µs unipolar pulses and bursts of 1 µs bipolar pulses. First, pulses were applied to potato tuber tissue while an infrared camera was used to monitor the temperature distribution in real-time as a corollary to the electric field distribution. The analytical solution was overlaid on the thermal images for a qualitative assessment of the electric fields. Second, potato ablations were performed and the lesion size was measured along the x- and y-axes. These values were compared to the analytical solution to quantify its ability to predict treatment outcomes. To analyze the dynamic impedance changes due to electroporation at different frequencies, electrical impedance measurements (1 Hz to 1 MHz) were made before and after the treatment of potato tissue. For high-frequency bipolar burst treatment, the thermal images closely mirrored the constant electric field contours. The potato tissue lesions differed from the analytical solution by 39.7 ± 1.3 % (x-axis) and 6.87 ± 6.26 % (y-axis) for conventional unipolar pulses, and 15.46 ± 1.37 % (x-axis) and 3.63 ± 5.9 % (y-axis) for high- frequency bipolar pulses. The electric field distributions due to high-frequency, bipolar electroporation pulses can be closely approximated with the homogeneous analytical solution. This paves way for modeling fields without prior characterization of non-linear tissue properties, and thereby simplifying electroporation procedures.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Taiwan 1 2%
Unknown 40 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 22%
Student > Master 6 15%
Student > Bachelor 5 12%
Researcher 5 12%
Lecturer 2 5%
Other 5 12%
Unknown 9 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 27%
Medicine and Dentistry 5 12%
Biochemistry, Genetics and Molecular Biology 4 10%
Engineering 3 7%
Immunology and Microbiology 2 5%
Other 4 10%
Unknown 12 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2019.
All research outputs
#5,013,100
of 15,886,334 outputs
Outputs from BioMedical Engineering OnLine
#142
of 660 outputs
Outputs of similar age
#107,291
of 277,497 outputs
Outputs of similar age from BioMedical Engineering OnLine
#1
of 2 outputs
Altmetric has tracked 15,886,334 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 660 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,497 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them