You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
| Title |
Induction of immune response in chickens primed in ovo with an inactivated H9N2 avian influenza virus vaccine
|
|---|---|
| Published in |
BMC Research Notes, July 2018
|
| DOI | 10.1186/s13104-018-3537-9 |
| Pubmed ID | |
| Authors |
Jake Astill, Tamiru Alkie, Alexander Yitbarek, Khaled Taha-Abdelaziz, Jegarubee Bavananthasivam, Éva Nagy, James John Petrik, Shayan Sharif |
| Abstract |
Infection of chickens with low pathogenic avian influenza virus, such as H9N2 virus, culminates in decreased egg production and increased mortality and morbidity if co-infection with other respiratory pathogens occurs. We have previously observed the induction of antibody- and cell-mediated immune responses after intramuscular administration of an H9N2 beta-propiolactone inactivated virus vaccine to chickens. Given the fact that in ovo vaccination represents a practical option for vaccination against H9N2 AIV in chickens, in the current study, we set out to characterize immune responses in chickens against a beta-propiolactone inactivated H9N2 virus vaccine after primary vaccination in ovo on embryonic day 18, and secondary intramuscular vaccination on day 14 post-hatch. We also included the Toll-like receptor 21 ligand, CpG ODN 2007, and an oil emulsion adjuvant, AddaVax™, as adjuvants for the vaccines. Antibody-mediated immune responses were observed after administering the secondary intramuscular vaccine. Cell-mediated immune responses were observed in chickens that received the beta-propiolactone inactivated H9N2 virus combined with AddaVax™. Our results demonstrate that adaptive immune responses can be induced in chickens after a primary in ovo vaccination and secondary intramuscular vaccination. |
Mendeley readers
The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 21 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 24% |
| Student > Master | 4 | 19% |
| Other | 2 | 10% |
| Researcher | 2 | 10% |
| Professor | 1 | 5% |
| Other | 2 | 10% |
| Unknown | 5 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 33% |
| Immunology and Microbiology | 3 | 14% |
| Unspecified | 1 | 5% |
| Biochemistry, Genetics and Molecular Biology | 1 | 5% |
| Veterinary Science and Veterinary Medicine | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 8 | 38% |