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Human osteoblasts exhibit sexual dimorphism in their response to estrogen on microstructured titanium surfaces

Overview of attention for article published in Biology of Sex Differences, July 2018
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2 tweeters

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36 Mendeley
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Title
Human osteoblasts exhibit sexual dimorphism in their response to estrogen on microstructured titanium surfaces
Published in
Biology of Sex Differences, July 2018
DOI 10.1186/s13293-018-0190-x
Pubmed ID
Authors

Michael B. Berger, David J. Cohen, Rene Olivares-Navarrete, Joseph K. Williams, David L. Cochran, Barbara D. Boyan, Zvi Schwartz

Abstract

Osseointegration is dependent on the implant surface, surrounding bone quality, and the systemic host environment, which can differ in male and female patients. Titanium (Ti) implants with microstructured surfaces exhibit greater pullout strength when compared to smooth-surfaced implants and exhibit enhanced osteogenic cellular responses in vitro. Previous studies showed that 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3] has a greater effect on rat osteoblast differentiation on microstructured Ti compared to smooth Ti surfaces and tissue culture polystyrene (TCPS). The stimulatory effect of 17β-estradiol (E2) on differentiation is observed in female osteoblasts on micro-rough Ti, but it is not known if male osteoblasts behave similarly in response to E2 and microtopography. This study assessed whether human male and female osteoblasts exhibit sex-specific differences in response to E2 and 1α,25(OH)2D3 when cultured on microstructured Ti surfaces. Osteoblasts from three male and three female human donors were cultured on Ti discs with varying surface profiles: a smooth pretreatment (PT), a coarse grit-blasted/acid-etched (SLA), and an SLA surface having undergone modification in a nitrogen environment and stored in saline to maintain hydrophilicity (modSLA). Cells cultured on these surfaces were treated with E2 or 1α,25(OH)2D3. Male and female human osteoblasts responded similarly to microstructure although there were donor-specific differences; cell number decreased, and osteocalcin (OCN), osteoprotegerin (OPG), and latent and active transforming growth factor 1 increased on SLA and modSLA compared to TCPS. Female osteoblasts had higher alkaline phosphatase activity and OCN production than male counterparts but produced less OPG. Both sexes responded similarly to 1α,25(OH)2D3. E2 treatment reduced cell number and increased osteoblast differentiation and factor production only in female cells. Male and female human osteoblasts respond similarly to microstructure and 1α,25(OH)2D3 but exhibit sexual dimorphism in substrate-dependent responses to E2. E2 affected female osteoblasts, suggesting that signaling is sex-specific and surface-dependent. Donor osteoblasts varied in response, demonstrating the need to test multiple donors when examining human samples. Understanding how male and female cells respond to orthopedic biomaterials will enable greater predictability post-implantation as well as therapies that are more patient-specific.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 36 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 14%
Student > Ph. D. Student 5 14%
Professor 4 11%
Student > Bachelor 3 8%
Student > Doctoral Student 2 6%
Other 7 19%
Unknown 10 28%
Readers by discipline Count As %
Medicine and Dentistry 11 31%
Biochemistry, Genetics and Molecular Biology 3 8%
Engineering 3 8%
Agricultural and Biological Sciences 1 3%
Immunology and Microbiology 1 3%
Other 4 11%
Unknown 13 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2018.
All research outputs
#7,904,502
of 13,260,816 outputs
Outputs from Biology of Sex Differences
#174
of 241 outputs
Outputs of similar age
#146,361
of 267,166 outputs
Outputs of similar age from Biology of Sex Differences
#3
of 3 outputs
Altmetric has tracked 13,260,816 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 241 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.4. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,166 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.