“poly(ADP-ribose) polymerase 1, catalyzes the transfer of a poly(ADP-ribose) (PAR) moiety from NAD+ onto acceptor proteins, including itself, histone proteins, and CTCF. “ https://t.co/E4V6Kqrm8E
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The first Nature Genetics (2004) report on Poly(ADP-ribosyl)ated CTCF has been published by Wenqiang Yu et. al. with V. Lobanenkov, E. Klenova, and R. Ohlsson under the following title: Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation.
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PARP1 inhibition represses immortalization of B cells - it binds the EBV genome together with CTCF!
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PARP1 Stabilizes CTCF Binding and Chromatin Structure To Maintain Epstein-Barr Virus Latency Type https://t.co/6IXbuMDVUk