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Low prevalence of CCR5-Δ32, CCR2-64I and SDF1-3′A alleles in the Baiga and Gond tribes of Central India

Overview of attention for article published in SpringerPlus, August 2015
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Title
Low prevalence of CCR5-Δ32, CCR2-64I and SDF1-3′A alleles in the Baiga and Gond tribes of Central India
Published in
SpringerPlus, August 2015
DOI 10.1186/s40064-015-1238-6
Pubmed ID
Authors

Deepak Bharti, Ashish Kumar, Ranjeet Singh Mahla, Sushil Kumar, Harshad Ingle, Tushar Yadav, Anamika Mishra, Ashwin Ashok Raut, Himanshu Kumar

Abstract

Human immunodeficiency virus-1 (HIV-1) which causes acquired immune deficiency syndrome (AIDS), by infecting CD4(+) immune cells and hence weakening the host defense mechanism till death, is one of the major factor responsible for human demises worldwide. Both innate (monocytes and macrophages) and adaptive (T cells) immune cells expresses chemokines receptors (2 and 5) and stromal cell derived factor-1 (SDF-1) which play crucial role in HIV-1 virus entry and progression. Allele variants of genes CCR5 (CCR5-Δ32), CCR2 (CCR2-64I) and SDF1 (SDFA-3'A; the ligand of CXCR4) are known to slow down the HIV-1 progression in infected individual. In the present study, the frequency of CCR5-Δ32, CCR2-64I and SDF1-3'A alleles in primitive tribe (Baiga) and a non-primitive tribe (Gond) of central India were investigated. A total 200 seronegative samples for HIV from healthy individuals of tribes were analyzed and observed allele frequencies of CCR5-Δ32, CCR2-64I and SDF1-3'A were (0, 0.035, 0.080) and (0, 0.110, 0.100) in Baiga and Gond respectively. Minor allele frequency of these alleles of Gond and Baiga tribes were compared with different populations of the world for relative hazard (RH), which indicate the risk of progression after infection of HIV1. The RH values were calculated based on genotypic frequency, showed the high RH value (RH1-AIDS1993-0.98, RH2-AIDS1987-0.98 and death/RH3-0.97) in Baiga tribe, indicates the low level of resistance against HIV-1 progression after infection.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 29%
Researcher 3 14%
Student > Bachelor 2 10%
Other 1 5%
Professor 1 5%
Other 3 14%
Unknown 5 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 19%
Agricultural and Biological Sciences 2 10%
Social Sciences 2 10%
Arts and Humanities 1 5%
Business, Management and Accounting 1 5%
Other 4 19%
Unknown 7 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 September 2015.
All research outputs
#20,290,425
of 22,826,360 outputs
Outputs from SpringerPlus
#1,460
of 1,850 outputs
Outputs of similar age
#224,694
of 267,538 outputs
Outputs of similar age from SpringerPlus
#94
of 119 outputs
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