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Surgical treatment of primitive gastro-intestinal lymphomas: a systematic review

Overview of attention for article published in World Journal of Surgical Oncology, November 2011
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Title
Surgical treatment of primitive gastro-intestinal lymphomas: a systematic review
Published in
World Journal of Surgical Oncology, November 2011
DOI 10.1186/1477-7819-9-145
Pubmed ID
Authors

Roberto Cirocchi, Eriberto Farinella, Stefano Trastulli, Davide Cavaliere, Piero Covarelli, Chiara Listorti, Jacopo Desiderio, Francesco Barberini, Nicola Avenia, Antonio Rulli, Giorgio Maria Verdecchia, Giuseppe Noya, Carlo Boselli

Abstract

Primitive Gastrointestinal Lymphomas (PGIL) are uncommon tumours, although time-trend analyses have demonstrated an increase. The role of surgery in the management of lymphoproliferative diseases has changed over the past 40 years. Nowadays their management is centred on systemic treatments as chemo-/radiotherapy. Surgery is restricted to very selected indications, always discussed in a multidisciplinary setting. The aim of this systematic review is to evaluate the actual role of surgery in the treatment of PGIL. A systematic review of literature was conducted according to the recommendations of The Cochrane Collaboration. Main outcomes analysed were overall survival (OS) and disease free survival (DFS). There are currently 1 RCT and 4 non-randomised prospective controlled studies comparing surgical versus medical treatment for PGIL. Seven hundred and one patients were analysed, divided into two groups: 318 who underwent to surgery alone or associated with chemotherapy and/or radiotherapy (surgical group) versus 383 who were treated with chemotherapy and/or radiotherapy (medical group). Despite the OS at 10 years between surgical and medical groups did not show relevant differences, the DFS was significantly better in the medical group (P=0.00001). Accordingly a trend was noticed in the recurrence rate, which was lower in the medical group (6.06 vs. 8.57%); and an higher mortality was revealed in the surgical group (4.51% vs. 1.50%).The chemotherapy confirms its primary role in the management of PGIL as part of systemic treatment in the medical group. Surgery remains the treatment of choice in case of PGIL acutely complicated, although there is no evidence in literature regarding the utility of preventive surgery.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ecuador 1 3%
Italy 1 3%
Unknown 28 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 13%
Student > Bachelor 4 13%
Student > Postgraduate 4 13%
Professor > Associate Professor 4 13%
Student > Master 3 10%
Other 5 17%
Unknown 6 20%
Readers by discipline Count As %
Medicine and Dentistry 24 80%
Unknown 6 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2011.
All research outputs
#13,357,126
of 22,656,971 outputs
Outputs from World Journal of Surgical Oncology
#361
of 2,038 outputs
Outputs of similar age
#86,545
of 142,328 outputs
Outputs of similar age from World Journal of Surgical Oncology
#3
of 46 outputs
Altmetric has tracked 22,656,971 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,038 research outputs from this source. They receive a mean Attention Score of 2.0. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 142,328 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.