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Chronic depressive symptomatology and CSF amyloid beta and tau levels in mild cognitive impairment

Overview of attention for article published in International Journal of Geriatric Psychiatry, June 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

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Title
Chronic depressive symptomatology and CSF amyloid beta and tau levels in mild cognitive impairment
Published in
International Journal of Geriatric Psychiatry, June 2018
DOI 10.1002/gps.4926
Pubmed ID
Authors

Mitzi M. Gonzales, Philip S. Insel, Craig Nelson, Duygu Tosun, Michael Schöll, Niklas Mattsson, Simona Sacuiu, David Bickford, Michael W. Weiner, R. Scott Mackin, the Alzheimer's Disease Neuroimaging Initiative

Abstract

To investigate the association between chronic subsyndromal symptoms of depression (SSD), cerebrospinal fluid (CSF) biomarkers, and neuropsychological performance in individuals with mild cognitive impairment (MCI). Participants included 238 older adults diagnosed with MCI from the Alzheimer's Disease Neuroimaging Initiative repository with cognitive and CSF amyloid beta (Aβ1-42 ), total tau (t-tau), and phosphorylated tau (p-tau) data. The Neuropsychiatric Inventory identified individuals with chronic endorsement (SSD group N = 80) or no endorsement (non-SSD group N = 158) of depressive symptoms across timepoints. CSF biomarker and cognitive performance were evaluated with linear regression models adjusting for age, education, gender, APOE genotype, global cognitive status, and SSD group. As compared to the non-SSD group, the SSD group displayed lower CSF Aβ1-42 levels (β = -24.293, S.E. = 6.345, P < 0.001). No group differences were observed for CSF t-tau (P = 0.497) or p-tau levels (P = 0.392). Lower CSF Aβ1-42 levels were associated with poorer performance on learning (β = 0.041, S.E. = 0.018, P = 0.021) and memory (β = -0.012, S.E. = 0.005, P = 0.031) measures, whereas higher CSF t-tau levels were associated with poorer performance on measures of global cognition (β = 0.022, S.E = 0.008, P = 0.007) and language (β = -0.010, S.E = 0.004, P = 0.019). SSD was independently associated with diminished global cognition, learning and memory, language, and executive function performance over and above the effects of CSF biomarkers (all P < 0.05). MCI participants with SSD displayed diminished CSF Aβ1-42 levels but did not differ from non-SSD controls in CSF tau levels. Additionally, CSF biomarkers and SSD independently accounted for variance in cognitive performance, suggesting that these factors may uniquely confer cognitive risk in MCI.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 87 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 14%
Student > Master 11 13%
Student > Doctoral Student 7 8%
Student > Bachelor 7 8%
Researcher 6 7%
Other 11 13%
Unknown 33 38%
Readers by discipline Count As %
Neuroscience 17 20%
Psychology 14 16%
Medicine and Dentistry 10 11%
Biochemistry, Genetics and Molecular Biology 3 3%
Social Sciences 3 3%
Other 5 6%
Unknown 35 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2019.
All research outputs
#3,375,147
of 24,411,829 outputs
Outputs from International Journal of Geriatric Psychiatry
#539
of 2,525 outputs
Outputs of similar age
#65,553
of 333,653 outputs
Outputs of similar age from International Journal of Geriatric Psychiatry
#10
of 40 outputs
Altmetric has tracked 24,411,829 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,525 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,653 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.