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No evidence in support of a prodromal respiratory control signature in the TgF344-AD rat model of Alzheimer’s disease

Overview of attention for article published in Respiratory Physiology & Neurobiology, July 2019
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (74th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
1 news outlet

Citations

dimensions_citation
4 Dimensions

Readers on

mendeley
25 Mendeley

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Summary News Dimensions citations
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Title
No evidence in support of a prodromal respiratory control signature in the TgF344-AD rat model of Alzheimer’s disease
Published in
Respiratory Physiology & Neurobiology, July 2019
DOI 10.1016/j.resp.2018.06.014
Pubmed ID
29969703
Authors

Eric F. Lucking, Kevin H. Murphy, David P. Burns, Anirudh V. Jaisimha, Kevin J. Barry-Murphy, Pardeep Dhaliwal, Barry Boland, Mark G. Rae, Ken D. O’Halloran

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative condition disturbing major brain networks, including those pivotal to the motor control of breathing. The aim of this study was to examine respiratory control in the TgF344-AD transgenic rat model of AD. At 8-11 months of age, basal minute ventilation and ventilatory responsiveness to chemostimulation were equivalent in conscious wild-type (WT) and TgF344-AD rats. Under urethane anesthesia, basal diaphragm and genioglossus EMG activities were similar in WT and TgF344-AD rats. The duration of phenylbiguanide-induced apnoea was significantly shorter in TgF344-AD rats compared with WT. Following bilateral cervical vagotomy, diaphragm and genioglossus EMG responsiveness to chemostimulation were intact in TgF344-AD rats. Amyloid precursor protein C-terminal fragments were elevated in the TgF344-AD brainstem, in the absence of amyloid-β accumulation or alterations in tau phosphorylation. Brainstem pro-inflammatory cytokine concentrations were not increased in TgF344-AD rats. We conclude that neural control of breathing is preserved in TgF344-AD rats at this stage of the disease.

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Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 16%
Professor 3 12%
Researcher 3 12%
Student > Ph. D. Student 3 12%
Lecturer 2 8%
Other 5 20%
Unknown 5 20%
Readers by discipline Count As %
Neuroscience 8 32%
Medicine and Dentistry 4 16%
Nursing and Health Professions 2 8%
Immunology and Microbiology 1 4%
Social Sciences 1 4%
Other 3 12%
Unknown 6 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2018.
All research outputs
#4,242,046
of 23,094,276 outputs
Outputs from Respiratory Physiology & Neurobiology
#107
of 995 outputs
Outputs of similar age
#85,020
of 348,643 outputs
Outputs of similar age from Respiratory Physiology & Neurobiology
#1
of 29 outputs
Altmetric has tracked 23,094,276 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 995 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 348,643 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.

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