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Energy metabolism and rheumatic diseases: from cell to organism

Overview of attention for article published in Arthritis Research & Therapy, June 2012
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33 Dimensions

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47 Mendeley
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Title
Energy metabolism and rheumatic diseases: from cell to organism
Published in
Arthritis Research & Therapy, June 2012
DOI 10.1186/ar3885
Pubmed ID
Authors

Cornelia M Spies, Rainer H Straub, Frank Buttgereit

Abstract

In rheumatic and other chronic inflammatory diseases, high amounts of energy for the activated immune system have to be provided and allocated by energy metabolism. In recent time many new insights have been gained into the control of the immune response through metabolic signals. Activation of immune cells as well as reduced nutrient supply and hypoxia in inflamed tissues cause stimulation of glycolysis and other cellular metabolic pathways. However, persistent cellular metabolic signals can promote ongoing chronic inflammation and loss of immune tolerance. On the organism level, the neuroendocrine immune response of the hypothalamic-pituitary adrenal axis and sympathetic nervous system, which is meant to overcome a transient inflammatory episode, can lead to metabolic disease sequelae if chronically activated. We conclude that, on cellular and organism levels, a prolonged energy appeal reaction is an important factor of chronic inflammatory disease etiology.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Czechia 1 2%
Unknown 46 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 19%
Professor > Associate Professor 6 13%
Student > Master 4 9%
Student > Bachelor 4 9%
Researcher 3 6%
Other 9 19%
Unknown 12 26%
Readers by discipline Count As %
Medicine and Dentistry 11 23%
Agricultural and Biological Sciences 10 21%
Biochemistry, Genetics and Molecular Biology 3 6%
Immunology and Microbiology 2 4%
Linguistics 1 2%
Other 4 9%
Unknown 16 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 September 2015.
All research outputs
#14,278,028
of 25,374,647 outputs
Outputs from Arthritis Research & Therapy
#2,081
of 3,381 outputs
Outputs of similar age
#97,677
of 177,478 outputs
Outputs of similar age from Arthritis Research & Therapy
#34
of 64 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 177,478 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.