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Attention Score in Context
| Title |
Disruption of maternal gut microbiota during gestation alters offspring microbiota and immunity
|
|---|---|
| Published in |
Microbiome, July 2018
|
| DOI | 10.1186/s40168-018-0511-7 |
| Pubmed ID | |
| Authors |
Donald D. Nyangahu, Katie S. Lennard, Bryan P. Brown, Matthew G. Darby, Jerome M. Wendoh, Enock Havyarimana, Peter Smith, James Butcher, Alain Stintzi, Nicola Mulder, William Horsnell, Heather B. Jaspan |
| Abstract |
Early life microbiota is an important determinant of immune and metabolic development and may have lasting consequences. The maternal gut microbiota during pregnancy or breastfeeding is important for defining infant gut microbiota. We hypothesized that maternal gut microbiota during pregnancy and breastfeeding is a critical determinant of infant immunity. To test this, pregnant BALB/c dams were fed vancomycin for 5 days prior to delivery (gestation; Mg), 14 days postpartum during nursing (Mn), or during gestation and nursing (Mgn), or no vancomycin (Mc). We analyzed adaptive immunity and gut microbiota in dams and pups at various times after delivery. In addition to direct alterations to maternal gut microbial composition, pup gut microbiota displayed lower α-diversity and distinct community clusters according to timing of maternal vancomycin. Vancomycin was undetectable in maternal and offspring sera, therefore the observed changes in the microbiota of stomach contents (as a proxy for breastmilk) and pup gut signify an indirect mechanism through which maternal intestinal microbiota influences extra-intestinal and neonatal commensal colonization. These effects on microbiota influenced both maternal and offspring immunity. Maternal immunity was altered, as demonstrated by significantly higher levels of both total IgG and IgM in Mgn and Mn breastmilk when compared to Mc. In pups, lymphocyte numbers in the spleens of Pg and Pn were significantly increased compared to Pc. This increase in cellularity was in part attributable to elevated numbers of both CD4+ T cells and B cells, most notable Follicular B cells. Our results indicate that perturbations to maternal gut microbiota dictate neonatal adaptive immunity. |
X Demographics
The data shown below were collected from the profiles of 59 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 14 | 24% |
| Australia | 5 | 8% |
| United States | 4 | 7% |
| Spain | 4 | 7% |
| South Africa | 2 | 3% |
| Canada | 2 | 3% |
| Luxembourg | 1 | 2% |
| France | 1 | 2% |
| Ireland | 1 | 2% |
| Other | 7 | 12% |
| Unknown | 18 | 31% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 33 | 56% |
| Scientists | 21 | 36% |
| Practitioners (doctors, other healthcare professionals) | 3 | 5% |
| Science communicators (journalists, bloggers, editors) | 2 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 225 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 225 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 41 | 18% |
| Student > Master | 32 | 14% |
| Researcher | 22 | 10% |
| Student > Doctoral Student | 20 | 9% |
| Student > Bachelor | 14 | 6% |
| Other | 33 | 15% |
| Unknown | 63 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 29 | 13% |
| Agricultural and Biological Sciences | 29 | 13% |
| Medicine and Dentistry | 26 | 12% |
| Biochemistry, Genetics and Molecular Biology | 24 | 11% |
| Nursing and Health Professions | 15 | 7% |
| Other | 32 | 14% |
| Unknown | 70 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 46. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 February 2022.
All research outputs
#920,593
of 25,711,518 outputs
Outputs from Microbiome
#252
of 1,790 outputs
Outputs of similar age
#19,402
of 341,672 outputs
Outputs of similar age from Microbiome
#10
of 54 outputs
Altmetric has tracked 25,711,518 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,790 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.9. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,672 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.