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Prevalence of neurocognitive disorders and depression in a Brazilian HIV population

Overview of attention for article published in this source, August 2015
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Title
Prevalence of neurocognitive disorders and depression in a Brazilian HIV population
Published by
SBMT, August 2015
DOI 10.1590/0037-8682-0034-2015
Pubmed ID
Authors

Flávio Trentin Troncoso, Lucieni de Oliveira Conterno

Abstract

Combined antiretroviral therapy has enabled human immunodeficiency virus (HIV) carriers to live longer. This increased life expectancy is associated with the occurrence of degenerative diseases, including HIV-associated neurocognitive disorders (HAND), which are diagnosed via a complex neuropsychological assessment. The International HIV Dementia Scale (IHDS) is a screening instrument validated in Brazil for use in the absence of neuropsychological evaluation. HIV patients are frequently diagnosed with depression. We aimed to determine the prevalence of neurocognitive impairment using the IHDS and depressive disorders using the Hamilton Rating Scale for Depression (HAM-D17), compare the IHDS performance with the performances on the Timed Gait Test (TGT), the Digit Symbol Coding Test (DS) and the Brazilian version of the Scale of Instrumental Activities of Daily Living (IADL), and evaluate the association between the IHDS performance and clinical-demographic variables. One hundred fourteen patients were evaluated in a cross-sectional study conducted in a public outpatient clinic for infectious diseases in Marília City, State of São Paulo, Brazil. Data were collected following consultation. Statistical analysis was performed in accordance with the nature and distribution of the data and hypotheses. According to the IHDS, 53.2% of the sampled patients were neuropsychologically impaired. According to the HAM-D17, 26.3% had depressive disorders. There were significant associations between the IHDS and the TGT and DS. Multiple regression analysis indicated that female gender, educational level, and cluster of differentiation 4 (CD4) levels were significantly and independently associated with neurocognitive impairment. The prevalence of neurocognitive impairment according to the IHDS is high and associated with female gender, education level, and low CD4 levels.

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Mendeley readers

The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Peru 1 <1%
Brazil 1 <1%
Unknown 119 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 24 20%
Student > Bachelor 21 17%
Student > Ph. D. Student 14 12%
Student > Postgraduate 11 9%
Researcher 11 9%
Other 19 16%
Unknown 21 17%
Readers by discipline Count As %
Medicine and Dentistry 40 33%
Psychology 15 12%
Neuroscience 7 6%
Nursing and Health Professions 7 6%
Social Sciences 4 3%
Other 17 14%
Unknown 31 26%