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Factors associated with quality of life in patients with Alzheimer’s disease

Overview of attention for article published in BMC Geriatrics, July 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • Average Attention Score compared to outputs of the same age and source

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1 blog
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2 X users
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1 Facebook page

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222 Mendeley
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Title
Factors associated with quality of life in patients with Alzheimer’s disease
Published in
BMC Geriatrics, July 2018
DOI 10.1186/s12877-018-0855-7
Pubmed ID
Authors

Coralie Barbe, Damien Jolly, Isabella Morrone, Aurore Wolak-Thierry, Moustapha Dramé, Jean-Luc Novella, Rachid Mahmoudi

Abstract

Evaluation of health-related quality of life (HRQoL) in patients with Alzheimer's disease (AD) is necessary to ensure optimal management. Several scales for assessing HRQoL of patients with AD exist, in particular the Quality of Life in Alzheimer's Disease (QoL-AD), which includes an evaluation by the caregiver of the patient's HRQoL. The aim of this study was to identify factors associated with patient, caregiver and overall HRQoL as assessed by the QoL-AD. Cross-sectional multicenter study in subjects aged 65 years and older, with mild to moderate AD. HRQoL scores from the QoL-AD were recorded (3 scores, corresponding to patient, caregiver and overall), as well as sociodemographic variables for the patient and the caregiver, and data from the geriatric cognitive assessment (cognitive, psycho-behavioral, functional evaluations). Caregiver burden was evaluated using the Zarit caregiver burden scale. Factors associated with each QoL-AD score were identified by multivariate linear regression using t-tests and β estimations. Study was registered in Clinical Trial.gov (NCT02814773). In total, 123 patients with AD were included. For the patient QoL-AD evaluation, depression was significantly associated with lower HRQoL (β = - 2.56 ± 1.28, p = 0.04), while polypharmacy (β = - 1.80 ± 0.99, p = 0.07) and anxiety (β = - 1.70 ± 1.01, p = 0.09) tended to be associated with lower HRQoL scores. In terms of caregiver evaluations, depression (β = - 3.46 ± 1.09, p = 0.002), polypharmacy (β = - 1.91 ± 0.92, p = 0.04) and the presence of caregiver burden (β = - 3.50 ± 0.91, p = 0.0002) were associated with lower HRQoL. For the overall evaluation, depression (β = - 3.26 ± 1.02, p = 0.002) and polypharmacy (β = - 1.85 ± 0.81, p = 0.03) were significantly related to lower HRQoL. Depression and polypharmacy were two factors influencing HRQoL in patients with AD, both by patient self-report and on the caregiver report. Thus, despite the discrepancies between HRQoL as assessed by patients with AD and HRQoL as assessed by their caregiver, the caregiver's assessment may be used to guide patient management when the patient can no longer complete QoL evaluations. Moreover, the association between caregiver burden and the caregiver's QoL-AD score underlines the need to take caregivers into consideration in the overall management of the AD patient.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 222 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 222 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 19 9%
Student > Bachelor 19 9%
Researcher 14 6%
Student > Ph. D. Student 14 6%
Student > Doctoral Student 12 5%
Other 38 17%
Unknown 106 48%
Readers by discipline Count As %
Nursing and Health Professions 34 15%
Medicine and Dentistry 32 14%
Psychology 14 6%
Neuroscience 9 4%
Biochemistry, Genetics and Molecular Biology 6 3%
Other 16 7%
Unknown 111 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2018.
All research outputs
#4,160,860
of 23,881,329 outputs
Outputs from BMC Geriatrics
#1,070
of 3,241 outputs
Outputs of similar age
#77,128
of 328,450 outputs
Outputs of similar age from BMC Geriatrics
#29
of 56 outputs
Altmetric has tracked 23,881,329 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,241 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.0. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,450 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.