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Comparison of topical tofacitinib and 0.1% hypochlorous acid in a murine atopic dermatitis model

Overview of attention for article published in BMC Pharmacology and Toxicology, July 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#1 of 270)
  • High Attention Score compared to outputs of the same age (99th percentile)

Mentioned by

news
38 news outlets

Citations

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1 Dimensions

Readers on

mendeley
7 Mendeley
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Title
Comparison of topical tofacitinib and 0.1% hypochlorous acid in a murine atopic dermatitis model
Published in
BMC Pharmacology and Toxicology, July 2018
DOI 10.1186/s40360-018-0232-3
Pubmed ID
Authors

Tomoki Fukuyama, Sarah Ehling, Jenny Wilzopolski, Wolfgang Bäumer

Abstract

Topical administration of PR022, 0.05% hypochlorous acid (HOCl) in gel has been demonstrated to be beneficial in a chronic murine atopic dermatitis model. In a follow up study we tested a higher concentration (0.1%) of PR022 HOCl gel in comparison to the Janus kinase inhibitor tofacitinib, both of which are currently in clinical phase studies for treatment of human atopic dermatitis. The effect of topically administered HOCl (0.1%) in gel was compared to a topical formulation of tofacitinib (0.5%) in a therapeutic setting on atopic dermatitis-like lesions in NC/Nga mice as well as itch behaviour. NC/Nga mice were sensitized with house dust mite allergen. After reaching visible lesions, mice were treated either topically with HOCl or tofacitinib or gel vehicle for 17 days. After termination of the study, dorsal root ganglia were isolated for ex vivo stimulation and skin samples were taken for cytokine determination in inflamed skin. When administered onto lesional skin of NC/Nga mice, both HOCl and tofacitinib reduced lesions and scratching behaviour. The reduced inflammatory response by HOCl and tofacitinib treatment was demonstrated by diminished inflammatory cytokines in affected skin tissue from NC/Nga mice. Dorsal root ganglia neurons re-stimulated with a range of mediators of itch showed a reduced response compared to the vehicle control mice, when isolated from tofacitinib or HOCl treated mice. These data indicate a similar beneficial potential of topical high dose PR022 HOCl (0.1%) in gel and tofacitinib, in a translational murine model of atopic dermatitis.

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Lecturer > Senior Lecturer 1 14%
Lecturer 1 14%
Student > Doctoral Student 1 14%
Student > Bachelor 1 14%
Researcher 1 14%
Other 1 14%
Unknown 1 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 29%
Pharmacology, Toxicology and Pharmaceutical Science 1 14%
Immunology and Microbiology 1 14%
Medicine and Dentistry 1 14%
Unknown 2 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 303. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2018.
All research outputs
#37,176
of 13,205,256 outputs
Outputs from BMC Pharmacology and Toxicology
#1
of 270 outputs
Outputs of similar age
#1,753
of 266,918 outputs
Outputs of similar age from BMC Pharmacology and Toxicology
#1
of 4 outputs
Altmetric has tracked 13,205,256 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 270 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,918 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them