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Role of frontal white matter and corpus callosum on social function in schizophrenia

Overview of attention for article published in Schizophrenia Research, December 2018
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Title
Role of frontal white matter and corpus callosum on social function in schizophrenia
Published in
Schizophrenia Research, December 2018
DOI 10.1016/j.schres.2018.07.009
Pubmed ID
Authors

Daisuke Koshiyama, Masaki Fukunaga, Naohiro Okada, Kentaro Morita, Kiyotaka Nemoto, Fumio Yamashita, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Sinead Kelly, Neda Jahanshad, Noriko Kudo, Hirotsugu Azechi, Yoshiyuki Watanabe, Gary Donohoe, Paul M. Thompson, Kiyoto Kasai, Ryota Hashimoto

Abstract

Patients with schizophrenia show severe impairment in social function and have difficulty in their daily social life. Although a recent large-scale multicenter study revealed alterations in white matter microstructures, the association between these anatomical changes and social dysfunction in schizophrenia remains unknown. Therefore, we investigated the association between the white matter integrity of regions of interest and social function in schizophrenia. A total of 149 patients with schizophrenia and 602 healthy comparison subjects (HCS) underwent DTI and completed the Picture Arrangement subtest of the Wechsler Adult Intelligence Scale-Third Edition and the Finance subscale of the University of California, San Diego, Performance-Based Skills Assessment Brief, as social indices of interest. The fractional anisotropy (FA) in the anterior corona radiata and corpus callosum was significantly lower in patients than in HCS, and the radial diffusivity (RD) in the anterior corona radiata and corpus callosum was significantly higher in patients. The Picture Arrangement and Finance scores were both significantly impaired in patients. The effect of the FA of the right anterior corona radiata on the Finance score and the Picture Arrangement score, of the RD of the right anterior corona radiata on the Picture Arrangement score, and of the RD of the corpus callosum on the Picture Arrangement score were significant. In conclusion, our results confirmed the association between structural connectivity in the right frontal white matter and corpus callosum and social function in schizophrenia. These findings may provide a foundation for developing an intervention for functional recovery in schizophrenia.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 23%
Researcher 4 13%
Student > Master 4 13%
Student > Bachelor 3 10%
Student > Doctoral Student 2 6%
Other 4 13%
Unknown 7 23%
Readers by discipline Count As %
Neuroscience 6 19%
Psychology 6 19%
Medicine and Dentistry 4 13%
Nursing and Health Professions 1 3%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 2 6%
Unknown 11 35%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 July 2018.
All research outputs
#11,520,332
of 14,537,474 outputs
Outputs from Schizophrenia Research
#3,198
of 3,988 outputs
Outputs of similar age
#203,843
of 273,210 outputs
Outputs of similar age from Schizophrenia Research
#85
of 128 outputs
Altmetric has tracked 14,537,474 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,988 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,210 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 128 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.