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Prevalence of βS-globin gene haplotypes, α-thalassemia (3.7 kb deletion) and redox status in patients with sickle cell anemia in the state of Paraná, Brazil

Overview of attention for article published in Genetics and Molecular Biology, August 2015
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Title
Prevalence of βS-globin gene haplotypes, α-thalassemia (3.7 kb deletion) and redox status in patients with sickle cell anemia in the state of Paraná, Brazil
Published in
Genetics and Molecular Biology, August 2015
DOI 10.1590/s1415-475738320140231
Pubmed ID
Authors

Eliana LitsukoTomimatsu Shimauti, Danilo Grunig Humberto Silva, Eniuce Menezes de Souza, Eduardo Alves de Almeida, Francismar Prestes Leal, Claudia Regina Bonini-Domingos

Abstract

The aim of this study was to determine the frequency of beta S-globin gene (β(S) globin) haplotypes and alpha thalassemia with 3.7 kb deletion (-α(3.7kb) thalassemia) in the northwest region of Paraná state, and to investigate the oxidative and clinical-hematological profile of β(S) globin carriers in this population. Of the 77 samples analyzed, 17 were Hb SS, 30 were Hb AS and 30 were Hb AA. The β(S)globin haplotypes and -α(3.7kb) thalassemia were identified using polymerase chain reaction.Trolox equivalent antioxidant capacity (TEAC) and lipid peroxidation (LPO) were assessed spectophotometrically. Serum melatonin levels were determined using high-performance liquid chromatography coupled to coulometric electrochemical detection. The haplotype frequencies in the SS individuals were as follows: Bantu- 21 (62%), Benin - 11 (32%) and Atypical- 2 (6%). Bantu/Benin was the most frequent genotype. Of the 47 SS and AS individuals assessed, 17% (n = 8) had the -α(3.7kb) mutation. Clinical manifestations, as well as serum melatonin, TEAC and LPO levels did not differ between Bantu/Bantu and Bantu/Benin individuals (p > 0.05). Both genotypes were associated with high LPO and TEAC levels and decreased melatonin concentration. These data suggest that the level of oxidative stress in patients with Bantu/Bantu and Bantu/Benin genotypes may overload the antioxidant capacity.

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The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 3%
Unknown 35 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 17%
Student > Bachelor 6 17%
Student > Master 5 14%
Student > Doctoral Student 2 6%
Researcher 2 6%
Other 7 19%
Unknown 8 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 25%
Medicine and Dentistry 7 19%
Agricultural and Biological Sciences 6 17%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Nursing and Health Professions 1 3%
Other 2 6%
Unknown 9 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2015.
All research outputs
#14,401,265
of 21,448,133 outputs
Outputs from Genetics and Molecular Biology
#265
of 265 outputs
Outputs of similar age
#146,779
of 255,005 outputs
Outputs of similar age from Genetics and Molecular Biology
#6
of 6 outputs
Altmetric has tracked 21,448,133 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 265 research outputs from this source. They receive a mean Attention Score of 2.7. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.