Aneuploid events, particularly monosomies, tend to reduce cell fitness. Work from 1st author Po-ru Loh, Steven McCarroll, and Alkes Price identifies -7/del(7q) in CHIP, suggesting cells can tolerate loss of Chr7. Does this provide any survival advantage? h
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@sebatlab @freeseek82 Good question @sebatlab. We focused here on mutations that yield clonal advantage, but we did previously find an effect that is due to inherited hyper-mutable haplotypes at a different locus that contains a genomic fragile site. Her
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اما نمونههای زیادی از این پدیده وجود داره. مثلا در زنان بعضی از سلولهای خونی یکی از کروموزومهای X خودشون رو ازدست میدن. https://t.co/3hyq4fgI11
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Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations | Nature https://t.co/5n9pmBP1tg