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Structure of the toxic core of α-synuclein from invisible crystals

Overview of attention for article published in Nature, September 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

Citations

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384 Dimensions

Readers on

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640 Mendeley
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4 CiteULike
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Title
Structure of the toxic core of α-synuclein from invisible crystals
Published in
Nature, September 2015
DOI 10.1038/nature15368
Pubmed ID
Authors

Jose A. Rodriguez, Magdalena I. Ivanova, Michael R. Sawaya, Duilio Cascio, Francis E. Reyes, Dan Shi, Smriti Sangwan, Elizabeth L. Guenther, Lisa M. Johnson, Meng Zhang, Lin Jiang, Mark A. Arbing, Brent L. Nannenga, Johan Hattne, Julian Whitelegge, Aaron S. Brewster, Marc Messerschmidt, Sébastien Boutet, Nicholas K. Sauter, Tamir Gonen, David S. Eisenberg

Abstract

The protein α-synuclein is the main component of Lewy bodies, the neuron-associated aggregates seen in Parkinson disease and other neurodegenerative pathologies. An 11-residue segment, which we term NACore, appears to be responsible for amyloid formation and cytotoxicity of human α-synuclein. Here we describe crystals of NACore that have dimensions smaller than the wavelength of visible light and thus are invisible by optical microscopy. As the crystals are thousands of times too small for structure determination by synchrotron X-ray diffraction, we use micro-electron diffraction to determine the structure at atomic resolution. The 1.4 Å resolution structure demonstrates that this method can determine previously unknown protein structures and here yields, to our knowledge, the highest resolution achieved by any cryo-electron microscopy method to date. The structure exhibits protofibrils built of pairs of face-to-face β-sheets. X-ray fibre diffraction patterns show the similarity of NACore to toxic fibrils of full-length α-synuclein. The NACore structure, together with that of a second segment, inspires a model for most of the ordered portion of the toxic, full-length α-synuclein fibril, presenting opportunities for the design of inhibitors of α-synuclein fibrils.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 640 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 9 1%
United Kingdom 6 <1%
Canada 1 <1%
France 1 <1%
Denmark 1 <1%
Japan 1 <1%
Chile 1 <1%
Poland 1 <1%
Unknown 619 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 184 29%
Researcher 141 22%
Student > Bachelor 64 10%
Student > Master 57 9%
Student > Doctoral Student 33 5%
Other 86 13%
Unknown 75 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 173 27%
Agricultural and Biological Sciences 156 24%
Chemistry 96 15%
Neuroscience 40 6%
Physics and Astronomy 24 4%
Other 62 10%
Unknown 89 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 67. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2016.
All research outputs
#418,194
of 18,901,471 outputs
Outputs from Nature
#20,332
of 82,777 outputs
Outputs of similar age
#6,977
of 249,639 outputs
Outputs of similar age from Nature
#451
of 959 outputs
Altmetric has tracked 18,901,471 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 82,777 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 93.2. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,639 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 959 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.