Title |
MiR-378 suppresses prostate cancer cell growth through downregulation of MAPK1 in vitro and in vivo
|
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Published in |
Tumor Biology, September 2015
|
DOI | 10.1007/s13277-015-3996-8 |
Pubmed ID | |
Authors |
Qi-guang Chen, Wei Zhou, Tao Han, Shu-qi Du, Zhen-hua Li, Zhe Zhang, Guang-yi Shan, Chui-ze Kong |
Abstract |
Prostate cancer is one of the biggest health problems for the aging male. To the present, the roles of dysregulated microRNAs in prostate cancer are still unclear. Here, we evaluated the anti-proliferative role of miR-378 in prostate cancer. And, we found that the expression of miR-378 was significantly downregulated in clinical prostate cancer tissues. In vitro assay suggested that overexpression of miR-378-suppressed prostate cancer cell migration and invasion promoted cell apoptosis. Furthermore, we identified and validated MAPK1 as a direct target of miR-378. Ectopic expression of MAPK1 rescues miR-378-suppressed cell migration and invasion. In vivo assay demonstrated that the stably miR-378-overexpressed prostate cancer cells displayed a significantly reduction in tumor growth. Taken together, our data suggested that miR-378 may act as a potential therapeutic target against human prostate cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 21% |
Student > Bachelor | 4 | 17% |
Student > Master | 3 | 13% |
Student > Doctoral Student | 2 | 8% |
Researcher | 2 | 8% |
Other | 5 | 21% |
Unknown | 3 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 29% |
Agricultural and Biological Sciences | 5 | 21% |
Medicine and Dentistry | 3 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Unspecified | 1 | 4% |
Other | 2 | 8% |
Unknown | 5 | 21% |