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Interleukin-18 as a diagnostic marker of adult-onset Still’s disease in older patients: a case report and review of the literature

Overview of attention for article published in Journal of Medical Case Reports, July 2018
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Title
Interleukin-18 as a diagnostic marker of adult-onset Still’s disease in older patients: a case report and review of the literature
Published in
Journal of Medical Case Reports, July 2018
DOI 10.1186/s13256-018-1735-7
Pubmed ID
Authors

Daisuke Usuda, Yoshiki Furumura, Kento Takeshima, Ryusho Sangen, Yasuhiro Kawai, Yuji Kasamaki, Yoshitsugu Iinuma, Tsugiyasu Kanda

Abstract

Adult onset Still's disease is a systemic auto-inflammatory condition of unknown etiology characterized by intermittent spiking high fever, an evanescent salmon-pink or erythematous maculopapular skin rash, arthralgia or arthritis, and leukocytosis. Recently, a high level of interleukin-18 has been reported as a new characteristic marker. On the other hand no reports have been published on high interleukin-18 as a marker in older patients. We report a case of adult onset Still's disease in an older patient successfully treated with steroids in which interleukin-18 was a useful marker of disease activity. A 66-year-old Asian woman presented to our hospital with fever and arthralgia. We diagnosed adult onset Still's disease based on Yamaguchi criteria and a history of a high spiking fever, salmon-colored rash, and bilateral pain to shoulders, knees, and wrists. In this case, a high serum level of interleukin-18 was a diagnostic parameter. Administration of 40 mg of prednisolone followed by subcutaneous administration of 200 mg cyclosporine daily resulted in a dramatic resolution of our patient's febrile episodes 2 months after admission. Prednisolone was tapered to 5 mg/day every 2 weeks and cyclosporine 200 mg/day was continued. Her serum interleukin-18 level was prominently decreased, and she was discharged 3 months after treatment. Serum interleukin-18 level may be a good diagnostic biomarker to monitor adult onset Still's disease activity in older patients, measuring levels in both the acute and convalescent phases.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 2 14%
Researcher 2 14%
Student > Doctoral Student 2 14%
Student > Bachelor 2 14%
Student > Ph. D. Student 1 7%
Other 4 29%
Unknown 1 7%
Readers by discipline Count As %
Medicine and Dentistry 6 43%
Nursing and Health Professions 2 14%
Unspecified 1 7%
Immunology and Microbiology 1 7%
Biochemistry, Genetics and Molecular Biology 1 7%
Other 1 7%
Unknown 2 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#10,531,953
of 13,221,142 outputs
Outputs from Journal of Medical Case Reports
#1,244
of 2,237 outputs
Outputs of similar age
#198,752
of 266,391 outputs
Outputs of similar age from Journal of Medical Case Reports
#1
of 1 outputs
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So far Altmetric has tracked 2,237 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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