Title |
Step-up fecal microbiota transplantation strategy: a pilot study for steroid-dependent ulcerative colitis
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Published in |
Journal of Translational Medicine, September 2015
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DOI | 10.1186/s12967-015-0646-2 |
Pubmed ID | |
Authors |
Bota Cui, Pan Li, Lijuan Xu, Youquan Zhao, Huiquan Wang, Zhaoyuan Peng, Hai’e Xu, Jie Xiang, Zhi He, Ting Zhang, Yongzhan Nie, Kaichun Wu, Daiming Fan, Guozhong Ji, Faming Zhang |
Abstract |
The strategy of using fecal microbiota transplantation (FMT) for refractory ulcerative colitis (UC) remains unclear if single FMT failed to induce remission. This study aimed to evaluate the efficacy and safety of a designed step-up FMT strategy for the steroid-dependent UC. Fifteen patients with steroid-dependent UC were enrolled, and treated with step-up FMT strategy. Follow-up clinical data was collected for a minimum of 3 months. Fecal microbiota composition before and post FMT of patients and related donors were analyzed by 16S rRNA sequencing. Eight of fourteen (57.1 %) patients achieved clinical improvement and were able to discontinue steroids following step-up FMT. One patient was lost to follow-up. Among the 8 patients who responded, five (35.7 %) received one FMT therapy, one (7.1 %) received two FMTs, and two (14.2 %) received two FMTs plus a scheduled course of steroids. Four (28.6 %) of the 8 patients who responded maintained long-term remission during follow-up (3-18 months). Six patients (42.9 %) failed to meet the criteria of clinical improvement and maintained steroid dependence, though three experienced transient or partial improvement. Microbiota analysis showed that FMT altered the composition greatly, and a microbiota composition highly similar to that of the donor emerged in the patients with successful treatment. No severe adverse events occurred during treatment and follow-up. Step-up FMT strategy shows promise as a therapeutic strategy for patients with steroid-dependent UC, likely due to the successful restructuring of gut microbial composition. ClinicalTrials.gov, Number NCT01790061. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 6 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 83% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | <1% |
Unknown | 160 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 24 | 15% |
Student > Master | 22 | 14% |
Student > Bachelor | 22 | 14% |
Student > Ph. D. Student | 16 | 10% |
Student > Postgraduate | 11 | 7% |
Other | 29 | 18% |
Unknown | 37 | 23% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 39 | 24% |
Immunology and Microbiology | 21 | 13% |
Agricultural and Biological Sciences | 14 | 9% |
Biochemistry, Genetics and Molecular Biology | 13 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
Other | 21 | 13% |
Unknown | 46 | 29% |