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Performance of MTBDRplus assay in detecting multidrug resistant tuberculosis at hospital level

Overview of attention for article published in BMC Research Notes, December 2017
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4 tweeters

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22 Mendeley
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Title
Performance of MTBDRplus assay in detecting multidrug resistant tuberculosis at hospital level
Published in
BMC Research Notes, December 2017
DOI 10.1186/s13104-017-2989-7
Pubmed ID
Authors

Abebaw Kebede, Daniel Demisse, Meazashwork Assefa, Zerihun Getachew, Bazezew Yenew, Yared Tedla, Gobena Ameni

Abstract

Multidrug-resistant tuberculosis (MDR-TB) case finding progressively increased in Ethiopia mainly as a result of the utilization of World Health Organization (WHO)-endorsed rapid technologies including MTBDRplus assay. However, there is inadequate data on routine testing performance of the MTBDRplus assay. Consequently, the aim of the study was to assess the routine performance of the MTBDRplus assay in detecting MDR-TB at St. Peter's TB Specialized Hospital. The sensitivity and specificity of MTBDRplus in detecting isoniazid (INH) resistance were 96.3 and 100%, respectively. While for rifampicin (RIF) 100% was recorded for both. Similarly, a sensitivity of 97.96% and a specificity of 100% was measured for detecting MDR-TB. Among 49 MTBDRplus RIF resistant isolates, 46 (93.9%) strains had rpoB mutation. S531L was the most common rpoB mutant (81.6% of RIF resistant cases). All MTBDRplus INH resistant isolates (n = 52) had S315T1 katG mutation.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 23%
Student > Master 3 14%
Professor 2 9%
Student > Bachelor 2 9%
Researcher 2 9%
Other 6 27%
Unknown 2 9%
Readers by discipline Count As %
Medicine and Dentistry 5 23%
Biochemistry, Genetics and Molecular Biology 5 23%
Immunology and Microbiology 3 14%
Mathematics 2 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 9%
Other 3 14%
Unknown 2 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#8,650,576
of 13,801,769 outputs
Outputs from BMC Research Notes
#1,571
of 3,137 outputs
Outputs of similar age
#161,296
of 269,843 outputs
Outputs of similar age from BMC Research Notes
#1
of 1 outputs
Altmetric has tracked 13,801,769 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,137 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,843 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them