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Glycation of the Major Milk Allergen β-Lactoglobulin Changes its Allergenicity by Alterations in Cellular Uptake and Degradation

Overview of attention for article published in Molecular Nutrition & Food Research, July 2018
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3 tweeters

Citations

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14 Dimensions

Readers on

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36 Mendeley
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Title
Glycation of the Major Milk Allergen β-Lactoglobulin Changes its Allergenicity by Alterations in Cellular Uptake and Degradation
Published in
Molecular Nutrition & Food Research, July 2018
DOI 10.1002/mnfr.201800341
Pubmed ID
Authors

Perusko, Marija, van Roest, Manon, Stanic-Vucinic, Dragana, Simons, Peter J., Pieters, Raymond, Velickovic, Tanja Cirkovic, Smit, Joost J.

Abstract

During food processing the Maillard reaction (МR) may occur resulting in the formation of glycated proteins. Glycated proteins are of particular importance in food allergy since glycation may influence interactions with immune system. This study compared native and extensively glycated milk allergen β-lactoglobulin (BLG), in their interactions with cells crucially involved in allergy. BLG was glycated in MR and characterized. Native and glycated BLG were tested in experiments of epithelial transport, uptake and degradation by DCs, T-cell cytokine responses and basophil cell degranulation using ELISA and flow cytometry. Glycation of BLG induced partial unfolding and reduced its intestinal epithelial transfer over a Caco-2 monolayer. Uptake of glycated BLG by bone marrow-derived dendritic cells (BMDC) was increased, although both BLG forms entered BMDC via the same mechanism, receptor-mediated endocytosis. Once inside the BMDC, glycated BLG was degraded faster, which might have led to observed lower cytokine production in BMDC/CD4+ T-cells coculture. Finally, glycated BLG was less efficient in induction of degranulation of BLG-specific IgE sensitized basophil cells. This study suggests that glycation of BLG by MR significantly alters its fate in processes involved in immunogenicity and allergenicity, pointing out the importance of food processing in food allergy. This article is protected by copyright. All rights reserved.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 36 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 22%
Student > Ph. D. Student 5 14%
Researcher 5 14%
Professor 4 11%
Lecturer 1 3%
Other 4 11%
Unknown 9 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 19%
Immunology and Microbiology 5 14%
Biochemistry, Genetics and Molecular Biology 3 8%
Engineering 2 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Other 5 14%
Unknown 12 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#7,445,441
of 13,221,142 outputs
Outputs from Molecular Nutrition & Food Research
#1,017
of 1,748 outputs
Outputs of similar age
#131,070
of 266,730 outputs
Outputs of similar age from Molecular Nutrition & Food Research
#13
of 28 outputs
Altmetric has tracked 13,221,142 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,748 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.4. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,730 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.