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Mendeley readers
Attention Score in Context
| Title |
Chromogenic in situ hybridization compared with other approaches to evaluate HER2/neu status in breast carcinomas
|
|---|---|
| Published in |
Brazilian Journal of Medical and Biological Research, March 2013
|
| DOI | 10.1590/1414-431x20132483 |
| Pubmed ID | |
| Authors |
F.E. Rosa, R.M. Santos, S.R. Rogatto, M.A.C. Domingues |
| Abstract |
Human epidermal growth factor receptor 2 (HER2) has been evaluated in breast cancer patients to identify those most likely to benefit from herceptin-targeted therapy. HER2 amplification, detected in 20-30% of invasive breast tumors, is associated with reduced survival and metastasis. The most frequently used technique for evaluating HER2 protein status as a routine procedure is immunohistochemistry (IHC). HER2 copy number alterations have also been evaluated by fluorescence in situ hybridization (FISH) in moderate immunoexpression (IHC 2+) cases. An alternative procedure to evaluate gene amplification is chromogenic in situ hybridization (CISH), which has some advantages over FISH, including the correlation between HER2 status and morphological features. Other methodologies have also been used, such as silver-enhanced in situ hybridization (SISH) and quantitative real-time RT-PCR, to determine the number of HER2 gene copies and expression, respectively. Here we will present a short and comprehensive review of the current advances concerning HER2 evaluation in human breast cancer. |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 62 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 12 | 19% |
| Student > Master | 10 | 16% |
| Researcher | 8 | 13% |
| Student > Ph. D. Student | 7 | 11% |
| Student > Postgraduate | 5 | 8% |
| Other | 9 | 14% |
| Unknown | 13 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 22% |
| Biochemistry, Genetics and Molecular Biology | 9 | 14% |
| Medicine and Dentistry | 9 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
| Psychology | 3 | 5% |
| Other | 13 | 20% |
| Unknown | 13 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 September 2015.
All research outputs
#8,534,528
of 25,371,288 outputs
Outputs from Brazilian Journal of Medical and Biological Research
#294
of 1,254 outputs
Outputs of similar age
#71,786
of 210,224 outputs
Outputs of similar age from Brazilian Journal of Medical and Biological Research
#3
of 9 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,254 research outputs from this source. They receive a mean Attention Score of 4.9. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,224 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.