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Ketanserin for Raynaud's phenomenon in progressive systemic sclerosis

Overview of attention for article published in Cochrane database of systematic reviews, April 1998
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (60th percentile)

Mentioned by

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1 Wikipedia page

Citations

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50 Dimensions

Readers on

mendeley
39 Mendeley
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Title
Ketanserin for Raynaud's phenomenon in progressive systemic sclerosis
Published in
Cochrane database of systematic reviews, April 1998
DOI 10.1002/14651858.cd000954
Pubmed ID
Authors

Janet Pope, D Fenlon, A Thompson, Beverley Shea, Dan Furst, George A Wells, Alan Silman

Abstract

To assess the effects and toxicity of the following agent: ketanserin versus placebo proposed for the treatment of Raynaud's phenomenon (RP) in scleroderma. We searched the Cochrane Controlled Trials Register, and Medline up to 1996 using the Cochrane Collaboration search strategy developed by Dickersin et al.(1994). Key words included: Raynaud's or vasospasm, scleroderma or progressive systematic sclerosis or connective tissue disease or autoimmune disease. Current Contents were searched up to and including April 7, 1997. All bibliographies of articles retrieved were searched and key experts in the area were contacted for additional and unpublished data. The initial search strategy included all languages. All randomized controlled trials comparing ketanserin versus placebo were eligible if they reported clinical outcomes of interest. Trials with dropout rates greater than 35% were excluded. Data were abstracted independently by two reviewers (DF, AT). Peto's odds ratios (OR) were calculated for all dichotomous outcomes, and a weighted mean difference (WMD) was carried out on all continuous outcomes. A fixed effects or random effects model were used if the data was homogeneous or heterogeneous, respectively. Three trials and 66 patients were included. The proportion improved was significantly better in the group on ketanserin with an odds ratio (OR) of 4.80 (95% CI 1.33, 17.37). However, when comparing ketanserin to placebo, the decrease in severity of RP attacks favoured placebo but this was not statistically significant. Side effects were significantly more common in the group using active treatment with an OR of 5.96 (95% CI 1.61, 22.06). Frequency of attacks did not change, but the duration of attacks decreased significantly in the ketanserin group. Ketanserin may have some efficacy in the treatment of Raynaud's phenomenon secondary to scleroderma. Overall, ketanserin is not significantly different from placebo for the treatment of Raynaud's phenomenon except for some decrease in the duration of attacks and more subjects improved on ketanserin compared to placebo. However, there were more side effects. It can be concluded that ketanserin treatment in Raynaud's phenomenon secondary to scleroderma is not clinically beneficial.

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 38 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 18%
Other 7 18%
Researcher 6 15%
Student > Bachelor 4 10%
Student > Ph. D. Student 3 8%
Other 5 13%
Unknown 7 18%
Readers by discipline Count As %
Medicine and Dentistry 22 56%
Nursing and Health Professions 2 5%
Agricultural and Biological Sciences 2 5%
Linguistics 1 3%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 2 5%
Unknown 9 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 July 2018.
All research outputs
#3,918,853
of 13,226,211 outputs
Outputs from Cochrane database of systematic reviews
#6,991
of 10,529 outputs
Outputs of similar age
#101,903
of 266,663 outputs
Outputs of similar age from Cochrane database of systematic reviews
#142
of 180 outputs
Altmetric has tracked 13,226,211 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,529 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.7. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,663 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 180 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.