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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Nasopharyngeal carriage and macrolide resistance in Indigenous children with bronchiectasis randomized to long-term azithromycin or placebo
|
|---|---|
| Published in |
European Journal of Clinical Microbiology & Infectious Diseases, September 2015
|
| DOI | 10.1007/s10096-015-2480-0 |
| Pubmed ID | |
| Authors |
K. M. Hare, K. Grimwood, A. B. Chang, M. D. Chatfield, P. C. Valery, A. J. Leach, H. C. Smith-Vaughan, P. S. Morris, C. A. Byrnes, P. J. Torzillo, A. C. Cheng |
| Abstract |
Although long-term azithromycin decreases exacerbation frequency in bronchiectasis, increased macrolide resistance is concerning. We investigated macrolide resistance determinants in a secondary analysis of a multicenter randomized controlled trial. Indigenous Australian children living in remote regions and urban New Zealand Māori and Pacific Islander children with bronchiectasis were randomized to weekly azithromycin (30 mg/kg) or placebo for up to 24 months and followed post-intervention for up to 12 months. Nurses administered and recorded medications given and collected nasopharyngeal swabs 3-6 monthly for culture and antimicrobial susceptibility testing. Nasopharyngeal carriage of Haemophilus influenzae and Moraxella catarrhalis was significantly lower in azithromycin compared to placebo groups, while macrolide-resistant Streptococcus pneumoniae and Staphylococcus aureus carriage was significantly higher. Australian children, compared to New Zealand children, had higher carriage overall, significantly higher carriage of macrolide-resistant bacteria at baseline (16/38 versus 2/40 children) and during the intervention (69/152 versus 22/239 swabs), and lower mean adherence to study medication (63 % versus 92 %). Adherence ≥70 % (versus <70 %) in the Australian azithromycin group was associated with lower carriage of any pathogen [odds ratio (OR) 0.19, 95 % confidence interval (CI) 0.07-0.53] and fewer macrolide-resistant pathogens (OR 0.34, 95 % CI 0.14-0.81). Post-intervention (median 6 months), macrolide resistance in S. pneumoniae declined significantly in the azithromycin group, from 79 % (11/14) to 7 % (1/14) of positive swabs, but S. aureus strains remained 100 % macrolide resistant. Azithromycin treatment, the Australian remote setting, and adherence <70 % were significant independent determinants of macrolide resistance in children with bronchiectasis. Adherence to treatment may limit macrolide resistance by suppressing carriage. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 86 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 13% |
| Researcher | 10 | 12% |
| Student > Bachelor | 9 | 10% |
| Student > Ph. D. Student | 8 | 9% |
| Student > Postgraduate | 7 | 8% |
| Other | 17 | 20% |
| Unknown | 24 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 31% |
| Nursing and Health Professions | 8 | 9% |
| Biochemistry, Genetics and Molecular Biology | 5 | 6% |
| Agricultural and Biological Sciences | 5 | 6% |
| Immunology and Microbiology | 3 | 3% |
| Other | 10 | 12% |
| Unknown | 28 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2015.
All research outputs
#18,426,826
of 22,828,180 outputs
Outputs from European Journal of Clinical Microbiology & Infectious Diseases
#2,161
of 2,772 outputs
Outputs of similar age
#193,039
of 267,845 outputs
Outputs of similar age from European Journal of Clinical Microbiology & Infectious Diseases
#27
of 37 outputs
Altmetric has tracked 22,828,180 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,772 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,845 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.