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The UK10K project identifies rare variants in health and disease

Overview of attention for article published in Nature, September 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

Mentioned by

news
7 news outlets
blogs
6 blogs
twitter
217 tweeters
facebook
8 Facebook pages
wikipedia
1 Wikipedia page
googleplus
1 Google+ user

Citations

dimensions_citation
536 Dimensions

Readers on

mendeley
859 Mendeley
citeulike
11 CiteULike
Title
The UK10K project identifies rare variants in health and disease
Published in
Nature, September 2015
DOI 10.1038/nature14962
Pubmed ID
Abstract

The contribution of rare and low-frequency variants to human traits is largely unexplored. Here we describe insights from sequencing whole genomes (low read depth, 7×) or exomes (high read depth, 80×) of nearly 10,000 individuals from population-based and disease collections. In extensively phenotyped cohorts we characterize over 24 million novel sequence variants, generate a highly accurate imputation reference panel and identify novel alleles associated with levels of triglycerides (APOB), adiponectin (ADIPOQ) and low-density lipoprotein cholesterol (LDLR and RGAG1) from single-marker and rare variant aggregation tests. We describe population structure and functional annotation of rare and low-frequency variants, use the data to estimate the benefits of sequencing for association studies, and summarize lessons from disease-specific collections. Finally, we make available an extensive resource, including individual-level genetic and phenotypic data and web-based tools to facilitate the exploration of association results.

Twitter Demographics

The data shown below were collected from the profiles of 217 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 859 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 17 2%
United Kingdom 15 2%
Germany 4 <1%
Spain 4 <1%
Canada 3 <1%
Italy 3 <1%
Hong Kong 2 <1%
India 2 <1%
France 2 <1%
Other 16 2%
Unknown 791 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 252 29%
Student > Ph. D. Student 209 24%
Student > Master 99 12%
Student > Bachelor 55 6%
Unspecified 55 6%
Other 187 22%
Unknown 2 <1%
Readers by discipline Count As %
Agricultural and Biological Sciences 318 37%
Biochemistry, Genetics and Molecular Biology 204 24%
Medicine and Dentistry 111 13%
Unspecified 97 11%
Computer Science 45 5%
Other 82 10%
Unknown 2 <1%

Attention Score in Context

This research output has an Altmetric Attention Score of 214. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 June 2019.
All research outputs
#62,987
of 13,767,716 outputs
Outputs from Nature
#6,612
of 70,609 outputs
Outputs of similar age
#1,451
of 240,914 outputs
Outputs of similar age from Nature
#244
of 964 outputs
Altmetric has tracked 13,767,716 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 70,609 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 77.8. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,914 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 964 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.