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Ionizable Amino‐Polyesters Synthesized via Ring Opening Polymerization of Tertiary Amino‐Alcohols for Tissue Selective mRNA Delivery

Overview of attention for article published in Advanced Materials, July 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

news
5 news outlets
blogs
1 blog
twitter
2 tweeters
patent
1 patent

Citations

dimensions_citation
59 Dimensions

Readers on

mendeley
145 Mendeley
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Title
Ionizable Amino‐Polyesters Synthesized via Ring Opening Polymerization of Tertiary Amino‐Alcohols for Tissue Selective mRNA Delivery
Published in
Advanced Materials, July 2018
DOI 10.1002/adma.201801151
Pubmed ID
Authors

Piotr S. Kowalski, Umberto Capasso Palmiero, Yuxuan Huang, Arnab Rudra, Robert Langer, Daniel G. Anderson

Abstract

The utility of messenger RNA (mRNA) as a therapy is gaining a broad interest due to its potential for addressing a wide range of diseases, while effective delivery of mRNA molecules to various tissues still poses a challenge. This study reports on the design and characterization of new ionizable amino-polyesters (APEs), synthesized via ring opening polymerization (ROP) of lactones with tertiary amino-alcohols that enable tissue and cell type selective delivery of mRNA. With a diverse library of APEs formulated into lipid nanoparticles (LNP), structure-activity parameters crucial for efficient transfection are established and APE-LNPs are identified that can preferentially home to and elicit effective mRNA expression with low in vivo toxicity in lung endothelium, liver hepatocytes, and splenic antigen presenting cells, including APE-LNP demonstrating nearly tenfold more potent systemic mRNA delivery to the lungs than vivo-jetPEI. Adopting tertiary amino-alcohols to initiate ROP of lactones allows to control polymer molecular weight and obtain amino-polyesters with narrow molecular weight distribution, exhibiting batch-to-batch consistency. All of which highlight the potential for clinical translation of APEs for systemic mRNA delivery and demonstrate the importance of employing controlled polymerization in the design of new polymeric nanomaterials to improve in vivo nucleic acid delivery.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 145 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 145 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 32 22%
Student > Master 18 12%
Researcher 15 10%
Student > Bachelor 14 10%
Student > Doctoral Student 8 6%
Other 25 17%
Unknown 33 23%
Readers by discipline Count As %
Chemistry 27 19%
Biochemistry, Genetics and Molecular Biology 21 14%
Pharmacology, Toxicology and Pharmaceutical Science 13 9%
Engineering 11 8%
Chemical Engineering 9 6%
Other 27 19%
Unknown 37 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 47. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2022.
All research outputs
#760,685
of 22,971,207 outputs
Outputs from Advanced Materials
#775
of 14,349 outputs
Outputs of similar age
#18,317
of 327,276 outputs
Outputs of similar age from Advanced Materials
#24
of 270 outputs
Altmetric has tracked 22,971,207 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,349 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.2. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,276 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 270 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.