↓ Skip to main content

The interplay between mutations in cagA, 23S rRNA, gyrA and drug resistance in Helicobacter pylori

Overview of attention for article published in Revista do Instituto de Medicina Tropical de Sao Paulo, June 2018
Altmetric Badge

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
4 Dimensions

Readers on

mendeley
20 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
The interplay between mutations in cagA, 23S rRNA, gyrA and drug resistance in Helicobacter pylori
Published in
Revista do Instituto de Medicina Tropical de Sao Paulo, June 2018
DOI 10.1590/s1678-9946201860025
Pubmed ID
Authors

Júlia Silveira Vianna, Ivy Bastos Ramis, Daniela Fernandes Ramos, Otávio Leite Gastal, Renato Azevedo da Silva, Carla Vitola Gonçalves, Pedro Eduardo Almeida da Silva

Abstract

In this study, we evaluated the mutations of Helicobacter pylori associated with resistance to clarithromycin and levofloxacin. Furthermore, based on the proposed interaction between antimicrobial resistance and pathogenicity, we correlated the mutation profiles of the strains with the presence of the pathogenicity gene cagA. We analyzed 80 gastric biopsy specimens from H. pylori-infected patients for point mutations in the 23S rRNA gene region and in the gyrA gene, which are related to clarithromycin and levofloxacin resistance, respectively, and investigated the presence of the cagA gene in these strains. We observed that in the assayed biopsies, 8.7% (7/80) had mutations in the 23S rRNA gene region at positions 2143 and 2142, while 22.5% (18/80) had mutations in gyrA at codons 87 and 91. Moreover, absence of the CagA-EPIYA pathogenicity factor was observed in 68% (17/25) of resistant samples. The knowledge of the local profile of antimicrobial resistance and the complex interplay involving resistance and pathogenicity can contribute to an appropriate clinical approach.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 25%
Student > Bachelor 3 15%
Other 2 10%
Student > Ph. D. Student 1 5%
Librarian 1 5%
Other 2 10%
Unknown 6 30%
Readers by discipline Count As %
Medicine and Dentistry 4 20%
Pharmacology, Toxicology and Pharmaceutical Science 2 10%
Biochemistry, Genetics and Molecular Biology 2 10%
Agricultural and Biological Sciences 2 10%
Immunology and Microbiology 2 10%
Other 3 15%
Unknown 5 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 July 2018.
All research outputs
#17,449,040
of 21,592,309 outputs
Outputs from Revista do Instituto de Medicina Tropical de Sao Paulo
#446
of 622 outputs
Outputs of similar age
#225,870
of 295,860 outputs
Outputs of similar age from Revista do Instituto de Medicina Tropical de Sao Paulo
#4
of 4 outputs
Altmetric has tracked 21,592,309 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 622 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 295,860 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.