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Impact of medication adherence on renal function in comorbid patients with type 2 diabetes and depression: protocol for a cohort study

Overview of attention for article published in BMC Primary Care, September 2015
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Title
Impact of medication adherence on renal function in comorbid patients with type 2 diabetes and depression: protocol for a cohort study
Published in
BMC Primary Care, September 2015
DOI 10.1186/s12875-015-0339-1
Pubmed ID
Authors

Hiroto Ito, Tosiya Sato, Noriko Satoh-Asahara, Mitsuhiko Noda

Abstract

Prevention, or slowing the progression, of diabetic nephropathy is one of the important goals in diabetes care. Although the impact of depression is a concern in patients with diabetes, it is unknown whether there is an association between adherence to hypoglycemic medication and the decline of renal function in comorbid patients with diabetes and depression. We will conduct a cohort study aimed at examining (1) depression as a predictor of renal function decline, and (2) how adherence to hypoglycemic medication relates to depression and renal function decline in patients with type 2 diabetes. In this multicenter cohort study, 550 patients with type 2 diabetes aged 20 years and older will be recruited at 20 outpatient clinics in general medicine and psychiatry. We will measure depression (Patient Health Questionnaire), medication adherence (medication possession ratio, Morisky Medication Adherence Scale, and one-item hypoglycemic medication adherence scale), and renal function (urinary albumin-creatinine ratio and estimated glomerular filtration rate) at baseline and at the 12-month follow-up. The primary endpoint is decline of renal function at 12 months. The secondary endpoints include clinical variables, quality of life, and the attitude of professionals toward depression. We will perform multivariable linear regression analysis to evaluate the effects of medication adherence on the decline of renal function in comorbid patients with type 2 diabetes and depression. To our knowledge, this will be the first study to examine how adherence to hypoglycemic medication relates to the decline of renal function in comorbid patients with type 2 diabetes and depression. The results of the study will have implications for practitioners of diabetes care, policy makers, and researchers for the prevention and treatment of diabetic nephropathy. UMIN000017513 (Registered on May 22, 2015).

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 75 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 15%
Student > Ph. D. Student 10 13%
Student > Master 9 12%
Student > Doctoral Student 8 11%
Student > Bachelor 5 7%
Other 16 21%
Unknown 16 21%
Readers by discipline Count As %
Medicine and Dentistry 18 24%
Psychology 12 16%
Nursing and Health Professions 6 8%
Social Sciences 6 8%
Pharmacology, Toxicology and Pharmaceutical Science 5 7%
Other 6 8%
Unknown 22 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2016.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from BMC Primary Care
#1,953
of 2,359 outputs
Outputs of similar age
#206,029
of 281,197 outputs
Outputs of similar age from BMC Primary Care
#54
of 61 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,359 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
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We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.