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Magnetogenetics: remote non-invasive magnetic activation of neuronal activity with a magnetoreceptor

Overview of attention for article published in Science Bulletin, September 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#9 of 1,783)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

news
3 news outlets
blogs
1 blog
twitter
302 X users
patent
2 patents
wikipedia
3 Wikipedia pages
googleplus
5 Google+ users

Citations

dimensions_citation
83 Dimensions

Readers on

mendeley
341 Mendeley
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Title
Magnetogenetics: remote non-invasive magnetic activation of neuronal activity with a magnetoreceptor
Published in
Science Bulletin, September 2015
DOI 10.1007/s11434-015-0902-0
Pubmed ID
Authors

Xiaoyang Long, Jing Ye, Di Zhao, Sheng-Jia Zhang

Abstract

Current neuromodulation techniques such as optogenetics and deep-brain stimulation are transforming basic and translational neuroscience. These two neuromodulation approaches are, however, invasive since surgical implantation of an optical fiber or wire electrode is required. Here, we have invented a non-invasive magnetogenetics that combines the genetic targeting of a magnetoreceptor with remote magnetic stimulation. The non-invasive activation of neurons was achieved by neuronal expression of an exogenous magnetoreceptor, an iron-sulfur cluster assembly protein 1 (Isca1). In HEK-293 cells and cultured hippocampal neurons expressing this magnetoreceptor, application of an external magnetic field resulted in membrane depolarization and calcium influx in a reproducible and reversible manner, as indicated by the ultrasensitive fluorescent calcium indicator GCaMP6s. Moreover, the magnetogenetic control of neuronal activity might be dependent on the direction of the magnetic field and exhibits on-response and off-response patterns for the external magnetic field applied. The activation of this magnetoreceptor can depolarize neurons and elicit trains of action potentials, which can be triggered repetitively with a remote magnetic field in whole-cell patch-clamp recording. In transgenic Caenorhabditis elegans expressing this magnetoreceptor in myo-3-specific muscle cells or mec-4-specific neurons, application of the external magnetic field triggered muscle contraction and withdrawal behavior of the worms, indicative of magnet-dependent activation of muscle cells and touch receptor neurons, respectively. The advantages of magnetogenetics over optogenetics are its exclusive non-invasive, deep penetration, long-term continuous dosing, unlimited accessibility, spatial uniformity and relative safety. Like optogenetics that has gone through decade-long improvements, magnetogenetics, with continuous modification and maturation, will reshape the current landscape of neuromodulation toolboxes and will have a broad range of applications to basic and translational neuroscience as well as other biological sciences. We envision a new age of magnetogenetics is coming.

X Demographics

X Demographics

The data shown below were collected from the profiles of 302 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 341 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 2%
China 5 1%
Spain 1 <1%
Unknown 329 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 92 27%
Researcher 57 17%
Student > Bachelor 34 10%
Student > Master 33 10%
Student > Doctoral Student 16 5%
Other 48 14%
Unknown 61 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 88 26%
Biochemistry, Genetics and Molecular Biology 46 13%
Neuroscience 46 13%
Engineering 34 10%
Physics and Astronomy 15 4%
Other 47 14%
Unknown 65 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 272. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2024.
All research outputs
#133,039
of 25,584,565 outputs
Outputs from Science Bulletin
#9
of 1,783 outputs
Outputs of similar age
#1,536
of 281,146 outputs
Outputs of similar age from Science Bulletin
#2
of 14 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,783 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,146 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.