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Analgesic effect of cathodal transcranial current stimulation over right dorsolateral prefrontal cortex in subjects with muscular temporomandibular disorders: study protocol for a randomized…

Overview of attention for article published in Trials, September 2015
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Title
Analgesic effect of cathodal transcranial current stimulation over right dorsolateral prefrontal cortex in subjects with muscular temporomandibular disorders: study protocol for a randomized controlled trial
Published in
Trials, September 2015
DOI 10.1186/s13063-015-0938-0
Pubmed ID
Authors

Rivail Almeida Brandão Filho, Abrahão Fontes Baptista, Renata de Assis Fonseca Santos Brandão, Francisco Monteiro Meneses, Jeffrey Okeson, Eduardo Pondé de Sena

Abstract

Temporomandibular disorders are a group of orofacial pain conditions that are commonly identified in the general population. Like many other chronic pain conditions, they can be associated with anxiety/depression, which can be related to changes in the activity of the dorsolateral prefrontal cortex. Some studies have demonstrated clinical improvement in subjects with chronic pain who are given therapeutic neuromodulation. Transcranial direct current stimulation is a noninvasive brain stimulation technique that allows the modulation of neuronal membranes. This therapy can enhance or inhibit action potential generation in cortical neurons. In some instances, medications acting in the central nervous system may be helpful despite their adverse side effects. It is important to determine if cathodal transcranial direct current stimulation over the dorsolateral prefrontal cortex, an area that modulates emotion and motor cortex excitability, has an analgesic effect on chronic temporomandibular disorders pain. The investigators will run a randomized, controlled crossover double blind study with 15 chronic muscular temporomandibular disorder subjects. Each subject will undergo active (1 mA and 2 mA) and sham transcranial direct current stimulation. Inclusion criteria will be determined by the Research Diagnostic Criteria for Temporomandibular Disorders questionnaire, with subjects who have a pain visual analogic scale score of greater than 4/10 and whose pain has been present for the previous 6 months, and with a State-Trait Anxiety Inventory score of more than 42. The influence of transcranial direct current stimulation will be assessed through a visual analogic scale, quantitative sensory testing, quantitative electroencephalogram, and the State-Trait Anxiety Inventory score. Some studies have demonstrated a strong association between anxiety/depression and chronic pain, where one may be the cause of the other. This is especially true in chronic temporomandibular disorders, and breaking this cycle may have an effect over the symptoms and associated dysfunction. We believe that by inhibiting activity of the dorsolateral prefrontal cortex though cathodal transcranial direct current stimulation, there may be a change in both anxiety/depression and pain level. Transcranial direct current stimulation may emerge as a new tool to be considered for managing these patients. We envision that the information obtained from this study will provide a better understanding of the management of chronic temporomandibular disorders. This trial was registered at clinicaltrials.gov on 24 May 2014 (Identifier: NCT02152267 ).

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 1%
Unknown 83 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 19 23%
Student > Bachelor 13 15%
Researcher 7 8%
Student > Ph. D. Student 7 8%
Student > Doctoral Student 7 8%
Other 20 24%
Unknown 11 13%
Readers by discipline Count As %
Medicine and Dentistry 26 31%
Neuroscience 16 19%
Nursing and Health Professions 7 8%
Psychology 5 6%
Social Sciences 4 5%
Other 10 12%
Unknown 16 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2016.
All research outputs
#10,132,657
of 11,426,369 outputs
Outputs from Trials
#2,431
of 2,707 outputs
Outputs of similar age
#197,385
of 241,039 outputs
Outputs of similar age from Trials
#114
of 122 outputs
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