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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The concerted roles of FANCM and Rad52 in the protection of common fragile sites
|
|---|---|
| Published in |
Nature Communications, July 2018
|
| DOI | 10.1038/s41467-018-05066-y |
| Pubmed ID | |
| Authors |
Hailong Wang, Shibo Li, Joshua Oaks, Jianping Ren, Lei Li, Xiaohua Wu |
| Abstract |
Common fragile sites (CFSs) are prone to chromosomal breakage and are hotspots for chromosomal rearrangements in cancer cells. We uncovered a novel function of Fanconi anemia (FA) protein FANCM in the protection of CFSs that is independent of the FA core complex and the FANCI-FANCD2 complex. FANCM, along with its binding partners FAAP24 and MHF1/2, is recruited to CFS-derived structure-prone AT-rich sequences, where it suppresses DNA double-strand break (DSB) formation and mitotic recombination in a manner dependent on FANCM translocase activity. Interestingly, we also identified an indispensable function of Rad52 in the repair of DSBs at CFS-derived AT-rich sequences, despite its nonessential function in general homologous recombination (HR) in mammalian cells. Suppression of Rad52 expression in combination with FANCM knockout drastically reduces cell and tumor growth, suggesting a synthetic lethality interaction between these two genes, which offers a potential targeted treatment strategy for FANCM-deficient tumors with Rad52 inhibition. |
X Demographics
The data shown below were collected from the profiles of 54 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 11 | 20% |
| Mexico | 5 | 9% |
| Chile | 4 | 7% |
| United States | 3 | 6% |
| Ecuador | 3 | 6% |
| Venezuela, Bolivarian Republic of | 2 | 4% |
| Peru | 1 | 2% |
| France | 1 | 2% |
| Portugal | 1 | 2% |
| Other | 4 | 7% |
| Unknown | 19 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 44 | 81% |
| Scientists | 9 | 17% |
| Practitioners (doctors, other healthcare professionals) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 98 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 21% |
| Researcher | 17 | 17% |
| Student > Master | 10 | 10% |
| Student > Bachelor | 7 | 7% |
| Other | 5 | 5% |
| Other | 13 | 13% |
| Unknown | 25 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 49 | 50% |
| Agricultural and Biological Sciences | 12 | 12% |
| Medicine and Dentistry | 2 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
| Computer Science | 1 | 1% |
| Other | 3 | 3% |
| Unknown | 30 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 117. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2018.
All research outputs
#348,923
of 25,028,065 outputs
Outputs from Nature Communications
#5,476
of 55,073 outputs
Outputs of similar age
#7,612
of 334,816 outputs
Outputs of similar age from Nature Communications
#150
of 1,309 outputs
Altmetric has tracked 25,028,065 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 55,073 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.9. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,816 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1,309 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.