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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The influence of obesity on survival in early, high-risk breast cancer: results from the randomized SUCCESS A trial
|
|---|---|
| Published in |
Breast Cancer Research, September 2015
|
| DOI | 10.1186/s13058-015-0639-3 |
| Pubmed ID | |
| Authors |
Peter Widschwendter, Thomas WP Friedl, Lukas Schwentner, Nikolaus DeGregorio, Bernadette Jaeger, Amelie Schramm, Inga Bekes, Miriam Deniz, Krisztian Lato, Tobias Weissenbacher, Bernd Kost, Ulrich Andergassen, Julia Jueckstock, Julia Neugebauer, Elisabeth Trapp, Peter A. Fasching, Matthias W. Beckmann, Andreas Schneeweiss, Ines Schrader, Brigitte Rack, Wolfgang Janni, Christoph Scholz |
| Abstract |
Obese breast cancer patients have worse prognosis than normal weight patients, but the level at which obesity is prognostically unfavorable is unclear. This retrospective analysis was performed using data from the SUCCESS A trial, in which 3754 patients with high-risk early breast cancer were randomized to anthracycline- and taxane-based chemotherapy with or without gemcitabine. Patients were classified as underweight/normal weight (body mass index (BMI) < 25.0), overweight (BMI 25.0-29.9), slightly obese (BMI 30.0-34.9), moderately obese (BMI 35.0-39.9) and severely obese (BMI ≥ 40.0), and the effect of BMI on disease-free survival (DFS) and overall survival (OS) was evaluated (median follow-up 65 months). In addition, subgroup analyses were conducted to assess the effect of BMI in luminal A-like, luminal B-like, HER2 (human epidermal growth factor 2)-positive and triple-negative tumors. Multivariate analyses revealed an independent prognostic effect of BMI on DFS (p = 0.001) and OS (p = 0.005). Compared with underweight/normal weight patients, severely obese patients had worse DFS (hazard ratio (HR) 2.70, 95 % confidence interval (CI) 1.71-4.28, p < 0.001) and OS (HR 2.79, 95 % CI 1.63-4.77, p < 0.001), while moderately obese, slightly obese and overweight patients did not differ from underweight/normal weight patients with regard to DFS or OS. Subgroup analyses showed a similar significant effect of BMI on DFS and OS in patients with triple-negative breast cancer (TNBC), but not in patients with other tumor subtypes. Severe obesity (BMI ≥ 40) significantly worsens prognosis in early breast cancer patients, particularly for triple-negative tumors. Clinicaltrials.gov NCT02181101 . Registered September 2005. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 22% |
| United Kingdom | 1 | 11% |
| United States | 1 | 11% |
| Unknown | 5 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 67% |
| Practitioners (doctors, other healthcare professionals) | 3 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 135 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | <1% |
| Unknown | 134 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 23 | 17% |
| Student > Master | 18 | 13% |
| Researcher | 16 | 12% |
| Other | 11 | 8% |
| Student > Ph. D. Student | 10 | 7% |
| Other | 24 | 18% |
| Unknown | 33 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 50 | 37% |
| Biochemistry, Genetics and Molecular Biology | 11 | 8% |
| Nursing and Health Professions | 11 | 8% |
| Agricultural and Biological Sciences | 11 | 8% |
| Sports and Recreations | 4 | 3% |
| Other | 15 | 11% |
| Unknown | 33 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2017.
All research outputs
#5,216,578
of 25,394,764 outputs
Outputs from Breast Cancer Research
#613
of 2,054 outputs
Outputs of similar age
#62,549
of 284,504 outputs
Outputs of similar age from Breast Cancer Research
#14
of 38 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,054 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,504 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.