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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Zinc ferrite nanoparticle-induced cytotoxicity and oxidative stress in different human cells
|
|---|---|
| Published in |
Cell & Bioscience, September 2015
|
| DOI | 10.1186/s13578-015-0046-6 |
| Pubmed ID | |
| Authors |
Hisham A. Alhadlaq, Mohd Javed Akhtar, Maqusood Ahamed |
| Abstract |
Zinc ferrite nanoparticles (NPs) have shown potential to be used in biomedical field such as magnetic resonance imaging and hyperthermia. However, there is limited information concerning the biological response of zinc ferrite NPs. This study was designed to evaluate the cytotoxicity of zinc ferrite NPs in three widely used in vitro cell culture models: human lung epithelial (A549), skin epithelial (A431) and liver (HepG2) cells. Zinc ferrite NPs were characterized by electron microscopy and dynamic light scattering. Cell viability, cell membrane damage, reactive oxygen species (ROS), glutathione (GSH), mitochondrial membrane potential (MMP), transcriptional level of apoptotic genes were determined in zinc ferrite NPs exposed cells. Zinc ferrite NPs were almost spherical shaped with an average size of 44 nm. Zinc ferrite NPs induced dose-dependent cytotoxicity (MTT and LDH) and oxidative stress (ROS and GSH) in all three types of cells in the dosage range of 10-40 µg/ml. Transcriptional level of tumor suppressor gene p53 and apoptotic genes (bax, caspase-3 and caspase-9) were up-regulated while the anti-apoptotic gene bcl-2 was down-regulated in cells after zinc ferrite NPs exposure. Furthermore, higher activity of caspase-3 and caspase-9 enzymes was also observed in zinc ferrite NPs treated cells. ROS generation, MMP loss and cell death in all three types of cells were abrogated by N-acetyl cysteine (ROS scavenger), which suggests that oxidative stress might be one of the plausible mechanisms of zinc ferrite NPs cytotoxicity. It is worth mentioning that there was marginally difference in the sensitivity of three cell lines against zinc ferrite NPs exposure. Cytotoxicity of zinc ferrite NPs were in following order; A549 > HepG2 > A431. Altogether, zinc ferrite NPs induced cytotoxicity and oxidative stress in A549, A431 and HepG2 cells, which is likely to be mediated through ROS generation. This study warrants further investigation to explore the potential mechanisms of toxicity of zinc ferrite NPs in normal cells as well as in animal models. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 82 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 18% |
| Researcher | 13 | 16% |
| Student > Master | 10 | 12% |
| Student > Doctoral Student | 8 | 10% |
| Student > Bachelor | 6 | 7% |
| Other | 10 | 12% |
| Unknown | 20 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 12% |
| Chemistry | 10 | 12% |
| Agricultural and Biological Sciences | 7 | 9% |
| Materials Science | 4 | 5% |
| Medicine and Dentistry | 4 | 5% |
| Other | 16 | 20% |
| Unknown | 31 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2015.
All research outputs
#18,426,826
of 22,828,180 outputs
Outputs from Cell & Bioscience
#558
of 930 outputs
Outputs of similar age
#196,003
of 272,396 outputs
Outputs of similar age from Cell & Bioscience
#7
of 11 outputs
Altmetric has tracked 22,828,180 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 930 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 272,396 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.