Title |
MicroRNAs in urine are not biomarkers of multiple myeloma
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Published in |
Journal of Negative Results in BioMedicine, September 2015
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DOI | 10.1186/s12952-015-0035-7 |
Pubmed ID | |
Authors |
Lenka Sedlaříková, Lenka Bešše, Soňa Novosadová, Veronika Kubaczková, Lenka Radová, Michal Staník, Marta Krejčí, Roman Hájek, Sabina Ševčíková |
Abstract |
In this study, we aimed to identify microRNA from urine of multiple myeloma patients that could serve as a biomarker for the disease. Analysis of urine samples was performed using Serum/Plasma Focus PCR MicroRNA Panel (Exiqon) and verified using individual TaqMan miRNA assays for qPCR. We found 20 deregulated microRNA (p < 0.05); for further validation, we chose 8 of them. Nevertheless, only differences in expression levels of miR-22-3p remained close to statistical significance. Our preliminary results did not confirm urine microRNA as a potential biomarker for multiple myeloma. |
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Country | Count | As % |
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Chile | 1 | 14% |
Mexico | 1 | 14% |
Unknown | 5 | 71% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 71% |
Scientists | 1 | 14% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 4 | 29% |
Student > Master | 2 | 14% |
Professor > Associate Professor | 2 | 14% |
Student > Ph. D. Student | 2 | 14% |
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Other | 3 | 21% |
Readers by discipline | Count | As % |
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Unspecified | 1 | 7% |
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Immunology and Microbiology | 1 | 7% |
Other | 1 | 7% |
Unknown | 2 | 14% |