Title |
Incidence and predictors of Lhermitte’s sign among patients receiving mediastinal radiation for lymphoma
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Published in |
Radiation Oncology, September 2015
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DOI | 10.1186/s13014-015-0504-7 |
Pubmed ID | |
Authors |
Bassem Youssef, JoAnn Shank, Jay P. Reddy, Chelsea C. Pinnix, George Farha, Mani Akhtari, Pamela K. Allen, Michelle A. Fanale, John A. Garcia, Patricia H. Horace, Sarah Milgrom, Grace Li Smith, Yago Nieto, Isadora Arzu, He Wang, Nathan Fowler, Maria Alma Rodriguez, Bouthaina Dabaja |
Abstract |
To prospectively examine the risk of developing Lhermitte's sign (LS) in patients with lymphoma treated with modern-era chemotherapy followed by consolidation intensity-modulated radiation therapy. We prospectively interviewed all patients with lymphoma who received irradiation to the mediastinum from July 2011 through April 2014. We extracted patient, disease, and treatment-related variables from the medical records of those patients and dosimetric variables from treatment-planning systems and analyzed these factors to identify potential predictors of LS with Pearson chi-square tests. During the study period 106 patients received mediastinal radiation for lymphoma, and 31 (29 %) developed LS. No correlations were found between LS and any of the variables examined, including total radiation dose, maximum point dose to the spinal cord, volume receiving 105 % of the dose, and volumes receiving 5 or 15 Gy. In this group of patients, treatment with chemotherapy followed by intensity-modulated radiation therapy led to 29 % developing LS; this symptom was independent of radiation dose and seemed to be an idiosyncratic reaction. This relatively high incidence could have resulted from prospective use of a structured interview. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 33% |
United States | 1 | 33% |
United Kingdom | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 4 | 27% |
Researcher | 3 | 20% |
Student > Doctoral Student | 2 | 13% |
Student > Postgraduate | 2 | 13% |
Student > Master | 2 | 13% |
Other | 1 | 7% |
Unknown | 1 | 7% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 47% |
Nursing and Health Professions | 2 | 13% |
Agricultural and Biological Sciences | 1 | 7% |
Arts and Humanities | 1 | 7% |
Social Sciences | 1 | 7% |
Other | 1 | 7% |
Unknown | 2 | 13% |