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Polyhydroxyalkanoate-based 3-hydroxyoctanoic acid and its derivatives as a platform of bioactive compounds

Overview of attention for article published in Applied Microbiology & Biotechnology, September 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

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2 tweeters

Citations

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36 Dimensions

Readers on

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52 Mendeley
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Title
Polyhydroxyalkanoate-based 3-hydroxyoctanoic acid and its derivatives as a platform of bioactive compounds
Published in
Applied Microbiology & Biotechnology, September 2015
DOI 10.1007/s00253-015-6984-4
Pubmed ID
Authors

Jelena Radivojevic, Sanja Skaro, Lidija Senerovic, Branka Vasiljevic, Maciej Guzik, Shane T. Kenny, Veselin Maslak, Jasmina Nikodinovic-Runic, Kevin E. O’Connor

Abstract

A library of 18 different compounds was synthesized starting from (R)-3-hydroxyoctanoic acid which is derived from the bacterial polymer polyhydroxyalkanoate (PHA). Ten derivatives, including halo and unsaturated methyl and benzyl esters, were synthesized and characterized for the first time. Given that (R)-3-hydroxyalkanoic acids are known to have biological activity, the new compounds were evaluated for antimicrobial activity and in vitro antiproliferative effect with mammalian cell lines. The presence of the carboxylic group was essential for the antimicrobial activity, with minimal inhibitory concentrations against a panel of bacteria (Gram-positive and Gram-negative) and fungi (Candida albicans and Microsporum gypseum) in the range 2.8-7.0 mM and 0.1-6.3 mM, respectively. 3-Halogenated octanoic acids exhibited the ability to inhibit C. albicans hyphae formation. In addition, (R)-3-hydroxyoctanoic and (E)-oct-2-enoic acids inhibited quorum sensing-regulated pyocyanin production in the opportunistic pathogen Pseudomonas aeruginosa PAO1. Generally, derivatives did not inhibit mammalian cell proliferation even at 3-mM concentrations, while only (E)-oct-2-enoic and 3-oxooctanoic acid had IC50 values of 1.7 and 1.6 mM with the human lung fibroblast cell line.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 19%
Researcher 9 17%
Student > Master 8 15%
Student > Bachelor 6 12%
Student > Doctoral Student 3 6%
Other 4 8%
Unknown 12 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 13%
Chemistry 6 12%
Engineering 5 10%
Biochemistry, Genetics and Molecular Biology 5 10%
Immunology and Microbiology 4 8%
Other 11 21%
Unknown 14 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2015.
All research outputs
#7,026,567
of 12,225,271 outputs
Outputs from Applied Microbiology & Biotechnology
#3,581
of 5,233 outputs
Outputs of similar age
#110,680
of 246,898 outputs
Outputs of similar age from Applied Microbiology & Biotechnology
#40
of 224 outputs
Altmetric has tracked 12,225,271 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,233 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 246,898 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 224 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.