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Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports

Overview of attention for article published in Journal of Neuropathology and Experimental Neurology, July 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#3 of 1,517)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
20 news outlets
blogs
1 blog
twitter
35 tweeters
facebook
1 Facebook page
googleplus
2 Google+ users
reddit
1 Redditor

Citations

dimensions_citation
32 Dimensions

Readers on

mendeley
102 Mendeley
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Title
Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports
Published in
Journal of Neuropathology and Experimental Neurology, July 2018
DOI 10.1093/jnen/nly065
Pubmed ID
Authors

Jason W Adams, Victor E Alvarez, Jesse Mez, Bertrand R Huber, Yorghos Tripodis, Weiming Xia, Gaoyuan Meng, Caroline A Kubilus, Kerry Cormier, Patrick T Kiernan, Daniel H Daneshvar, Alicia S Chua, Sarah Svirsky, Raymond Nicks, Bobak Abdolmohammadi, Laney Evers, Todd M Solomon, Jonathan D Cherry, Nurgul Aytan, Ian Mahar, Sherral Devine, Sanford Auerbach, Michael L Alosco, Christopher J Nowinski, Neil W Kowall, Lee E Goldstein, Brigid Dwyer, Douglas I Katz, Robert C Cantu, Robert A Stern, Rhoda Au, Ann C McKee, Thor D Stein

Abstract

Traumatic brain injury has been associated with increased risk of Parkinson disease and parkinsonism, and parkinsonism and Lewy body disease (LBD) can occur with chronic traumatic encephalopathy (CTE). To test whether contact sports and CTE are associated with LBD, we compared deceased contact sports athletes (n = 269) to cohorts from the community (n = 164) and the Boston University Alzheimer disease (AD) Center (n = 261). Participants with CTE and LBD were more likely to have β-amyloid deposition, dementia, and parkinsonism than CTE alone (p < 0.05). Traditional and hierarchical clustering showed a similar pattern of LBD distribution in CTE compared to LBD alone that was most frequently neocortical, limbic, or brainstem. In the community-based cohort, years of contact sports play were associated with neocortical LBD (OR = 1.30 per year, p = 0.012), and in a pooled analysis a threshold of >8 years of play best predicted neocortical LBD (ROC analysis, OR = 6.24, 95% CI = 1.5-25, p = 0.011), adjusting for age, sex, and APOE ɛ4 allele status. Clinically, dementia was significantly associated with neocortical LBD, CTE stage, and AD; parkinsonism was associated with LBD pathology but not CTE stage. Contact sports participation may increase risk of developing neocortical LBD, and increased LBD frequency may partially explain extrapyramidal motor symptoms sometimes observed in CTE.

Twitter Demographics

The data shown below were collected from the profiles of 35 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 102 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 15 15%
Student > Ph. D. Student 15 15%
Researcher 13 13%
Student > Master 11 11%
Student > Doctoral Student 6 6%
Other 18 18%
Unknown 24 24%
Readers by discipline Count As %
Medicine and Dentistry 20 20%
Neuroscience 15 15%
Psychology 8 8%
Sports and Recreations 5 5%
Social Sciences 4 4%
Other 19 19%
Unknown 31 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 182. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2020.
All research outputs
#119,718
of 17,520,445 outputs
Outputs from Journal of Neuropathology and Experimental Neurology
#3
of 1,517 outputs
Outputs of similar age
#3,722
of 285,529 outputs
Outputs of similar age from Journal of Neuropathology and Experimental Neurology
#1
of 25 outputs
Altmetric has tracked 17,520,445 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,517 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,529 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.