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Scutoids are a geometrical solution to three-dimensional packing of epithelia

Overview of attention for article published in Nature Communications, July 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#12 of 23,272)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

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11 Dimensions

Readers on

mendeley
182 Mendeley
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1 CiteULike
Title
Scutoids are a geometrical solution to three-dimensional packing of epithelia
Published in
Nature Communications, July 2018
DOI 10.1038/s41467-018-05376-1
Pubmed ID
Authors

Pedro Gómez-Gálvez, Pablo Vicente-Munuera, Antonio Tagua, Cristina Forja, Ana M. Castro, Marta Letrán, Andrea Valencia-Expósito, Clara Grima, Marina Bermúdez-Gallardo, Óscar Serrano-Pérez-Higueras, Florencia Cavodeassi, Sol Sotillos, María D. Martín-Bermudo, Alberto Márquez, Javier Buceta, Luis M. Escudero

Abstract

As animals develop, tissue bending contributes to shape the organs into complex three-dimensional structures. However, the architecture and packing of curved epithelia remains largely unknown. Here we show by means of mathematical modelling that cells in bent epithelia can undergo intercalations along the apico-basal axis. This phenomenon forces cells to have different neighbours in their basal and apical surfaces. As a consequence, epithelial cells adopt a novel shape that we term "scutoid". The detailed analysis of diverse tissues confirms that generation of apico-basal intercalations between cells is a common feature during morphogenesis. Using biophysical arguments, we propose that scutoids make possible the minimization of the tissue energy and stabilize three-dimensional packing. Hence, we conclude that scutoids are one of nature's solutions to achieve epithelial bending. Our findings pave the way to understand the three-dimensional organization of epithelial organs.

Twitter Demographics

The data shown below were collected from the profiles of 2,077 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 182 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 182 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 57 31%
Researcher 29 16%
Student > Master 18 10%
Student > Bachelor 17 9%
Student > Doctoral Student 14 8%
Other 46 25%
Unknown 1 <1%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 37 20%
Agricultural and Biological Sciences 26 14%
Engineering 19 10%
Unspecified 17 9%
Medicine and Dentistry 17 9%
Other 65 36%
Unknown 1 <1%

Attention Score in Context

This research output has an Altmetric Attention Score of 1623. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2019.
All research outputs
#1,222
of 13,238,738 outputs
Outputs from Nature Communications
#12
of 23,272 outputs
Outputs of similar age
#74
of 268,403 outputs
Outputs of similar age from Nature Communications
#1
of 441 outputs
Altmetric has tracked 13,238,738 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 23,272 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 46.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,403 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 441 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.