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Helicobacter pylori eradication: influence of interleukin-1beta –31 C/T polymorphism

Overview of attention for article published in Brazilian Journal of Infectious Diseases, January 2018
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Title
Helicobacter pylori eradication: influence of interleukin-1beta –31 C/T polymorphism
Published in
Brazilian Journal of Infectious Diseases, January 2018
DOI 10.1016/j.bjid.2018.06.005
Pubmed ID
Authors

Tássia Flores Rech, Luiz Edmundo Mazzoleni, Felipe Mazzoleni, Carlos Fernando de Magalhães Francesconi, Guilherme Becker Sander, Rafael Tomoya Michita, Débora Dreher Nabinger, Tobias Cancian Milbradt, Ronaldo João Spinato Torresini, Daniel Simon

Abstract

To analyze the influence of the -31 C/T polymorphism of the interleukin-1β gene on Helicobacter pylori eradication therapy success in patients with functional dyspepsia. Functional dyspepsia was diagnosed according to the Rome III criteria. All patients underwent upper gastrointestinal endoscopy, and gastric biopsies were obtained at screening and 12 months after randomization (last follow-up visit). Urease test and histological examination were performed to define the H. pylori status. Patients received twice-daily amoxicillin, clarithromycin and omeprazole for 10 days. Genotyping of the IL1B -31 C/T polymorphism (rs1143627) was performed using polymerase chain reaction-restriction fragment length polymorphism. One hundred forty-nine patients received treatment with triple therapy for H. pylori eradication. Only one patient was lost to follow-up, and adherence to study medication was 94.6%. A total of 148 patients (mean age 46.08 ± 12.24 years; 81.8% women) were evaluated for the influence of the IL1B -31 C/T polymorphism on the outcome of H. pylori eradication therapy. After treatment, bacteria were eradicated in 87% of patients (129/148). Genotype frequencies of the IL1B -31 C/T polymorphism were as follows: CC, 38/148 (25.7%); CT, 71/148 (47.9%); and TT, 39/148 (26.4%). Successful eradication rate was 78.9%, 94.4% and 82.1% for the CC, CT and TT genotypes, respectively. The CT genotype was significantly associated with successful H. pylori eradication (p = 0.039). This study suggests that the CT genotype of the IL1B -31 C/T polymorphism plays a role in the successful eradication of H. pylori among patients with functional dyspepsia.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 21%
Student > Bachelor 5 13%
Student > Doctoral Student 3 8%
Student > Ph. D. Student 3 8%
Other 2 5%
Other 5 13%
Unknown 13 33%
Readers by discipline Count As %
Medicine and Dentistry 10 26%
Pharmacology, Toxicology and Pharmaceutical Science 5 13%
Biochemistry, Genetics and Molecular Biology 3 8%
Immunology and Microbiology 3 8%
Agricultural and Biological Sciences 2 5%
Other 4 10%
Unknown 12 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2018.
All research outputs
#19,069,905
of 21,431,229 outputs
Outputs from Brazilian Journal of Infectious Diseases
#546
of 629 outputs
Outputs of similar age
#260,477
of 299,324 outputs
Outputs of similar age from Brazilian Journal of Infectious Diseases
#12
of 14 outputs
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So far Altmetric has tracked 629 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.