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Impaired mitochondrial biogenesis is a common feature to myocardial hypertrophy and end-stage ischemic heart failure

Overview of attention for article published in Cardiovascular Pathology, March 2016
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Title
Impaired mitochondrial biogenesis is a common feature to myocardial hypertrophy and end-stage ischemic heart failure
Published in
Cardiovascular Pathology, March 2016
DOI 10.1016/j.carpath.2015.09.009
Pubmed ID
Authors

Annalinda Pisano, Bruna Cerbelli, Elena Perli, Maria Pelullo, Valentina Bargelli, Carmela Preziuso, Massimiliano Mancini, Langping He, Matthew GD Bates, Joaquin R Lucena, Paola Lilla Della Monica, Giuseppe Familiari, Vincenzo Petrozza, Chiara Nediani, Robert W Taylor, Giulia d’Amati, Carla Giordano

Abstract

Mitochondrial (mt) DNA depletion and oxidative mtDNA damage have been implicated in the process of pathological cardiac remodeling. Whether these features are present in the early phase of maladaptive cardiac remodeling, that is, during compensated cardiac hypertrophy, is still unknown. We compared the morphologic and molecular features of mt biogenesis and markers of oxidative stress in human heart from adult subjects with compensated hypertrophic cardiomyopathy and heart failure. We have shown that mtDNA depletion is a constant feature of both conditions. A quantitative loss of mtDNA content was associated with significant down-regulation of selected modulators of mt biogenesis and decreased expression of proteins involved in mtDNA maintenance. Interestingly, mtDNA depletion characterized also the end-stage phase of cardiomyopathies due to a primary mtDNA defect. Oxidative stress damage was detected only in failing myocardium.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 25%
Researcher 9 17%
Student > Master 8 15%
Professor > Associate Professor 3 6%
Student > Postgraduate 3 6%
Other 6 12%
Unknown 10 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 25%
Biochemistry, Genetics and Molecular Biology 12 23%
Medicine and Dentistry 5 10%
Psychology 2 4%
Veterinary Science and Veterinary Medicine 1 2%
Other 5 10%
Unknown 14 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 September 2015.
All research outputs
#13,174,468
of 16,578,610 outputs
Outputs from Cardiovascular Pathology
#332
of 422 outputs
Outputs of similar age
#174,107
of 252,592 outputs
Outputs of similar age from Cardiovascular Pathology
#15
of 19 outputs
Altmetric has tracked 16,578,610 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 422 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
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We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.