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Understanding the molecular basis of autism in a dish using hiPSCs-derived neurons from ASD patients

Overview of attention for article published in Molecular Brain, September 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

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6 X users
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3 patents

Citations

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14 Dimensions

Readers on

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136 Mendeley
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Title
Understanding the molecular basis of autism in a dish using hiPSCs-derived neurons from ASD patients
Published in
Molecular Brain, September 2015
DOI 10.1186/s13041-015-0146-6
Pubmed ID
Authors

Chae-Seok Lim, Jung-eun Yang, You-Kyung Lee, Kyungmin Lee, Jin-A Lee, Bong-Kiun Kaang

Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by deficits in social cognition, language development, and repetitive/restricted behaviors. Due to the complexity and heterogeneity of ASD and lack of a proper human cellular model system, the pathophysiological mechanism of ASD during the developmental process is largely unknown. However, recent progress in induced pluripotent stem cell (iPSC) technology as well as in vitro neural differentiation techniques have allowed us to functionally characterize neurons and analyze cortical development during neural differentiation. These technical advances will increase our understanding of the pathogenic mechanisms of heterogeneous ASD and help identify molecular biomarkers for patient stratification as well as personalized medicine. In this review, we summarize our current knowledge of iPSC generation, differentiation of specific neuronal subtypes from iPSCs, and phenotypic characterizations of human ASD patient-derived iPSC models. Finally, we discuss the current limitations of iPSC technology and future directions of ASD pathophysiology studies using iPSCs.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Spain 1 <1%
Unknown 134 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 20%
Researcher 24 18%
Student > Bachelor 19 14%
Student > Master 14 10%
Student > Doctoral Student 9 7%
Other 29 21%
Unknown 14 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 20%
Neuroscience 25 18%
Biochemistry, Genetics and Molecular Biology 19 14%
Medicine and Dentistry 16 12%
Psychology 11 8%
Other 18 13%
Unknown 20 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 August 2021.
All research outputs
#4,522,788
of 22,829,083 outputs
Outputs from Molecular Brain
#237
of 1,110 outputs
Outputs of similar age
#59,973
of 274,274 outputs
Outputs of similar age from Molecular Brain
#7
of 20 outputs
Altmetric has tracked 22,829,083 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,110 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,274 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.