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The involvement of tau in nucleolar transcription and the stress response

Overview of attention for article published in Acta Neuropathologica Communications, July 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)

Mentioned by

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1 news outlet
twitter
18 tweeters
wikipedia
1 Wikipedia page

Citations

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28 Dimensions

Readers on

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65 Mendeley
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Title
The involvement of tau in nucleolar transcription and the stress response
Published in
Acta Neuropathologica Communications, July 2018
DOI 10.1186/s40478-018-0565-6
Pubmed ID
Authors

Mahmoud B. Maina, Laura J. Bailey, Sherin Wagih, Luca Biasetti, Saskia J. Pollack, James P. Quinn, Julian R. Thorpe, Aidan J. Doherty, Louise C. Serpell

Abstract

Tau is known for its pathological role in neurodegenerative diseases, including Alzheimer's disease (AD) and other tauopathies. Tau is found in many subcellular compartments such as the cytosol and the nucleus. Although its normal role in microtubule binding is well established, its nuclear role is still unclear. Here, we reveal that tau localises to the nucleolus in undifferentiated and differentiated neuroblastoma cells (SHSY5Y), where it associates with TIP5, a key player in heterochromatin stability and ribosomal DNA (rDNA) transcriptional repression. Immunogold labelling on human brain sample confirms the physiological relevance of this finding by showing tau within the nucleolus colocalises with TIP5. Depletion of tau results in an increase in rDNA transcription with an associated decrease in heterochromatin and DNA methylation, suggesting that under normal conditions tau is involved in silencing of the rDNA. Cellular stress induced by glutamate causes nucleolar stress associated with the redistribution of nucleolar non-phosphorylated tau, in a similar manner to fibrillarin, and nuclear upsurge of phosphorylated tau (Thr231) which doesn't colocalise with fibrillarin or nucleolar tau. This suggests that stress may impact on different nuclear tau species. In addition to involvement in rDNA transcription, nucleolar non-phosphorylated tau also undergoes stress-induced redistribution similar to many nucleolar proteins.

Twitter Demographics

The data shown below were collected from the profiles of 18 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 65 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 20%
Student > Bachelor 12 18%
Student > Master 9 14%
Student > Doctoral Student 6 9%
Student > Postgraduate 6 9%
Other 13 20%
Unknown 6 9%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 29 45%
Neuroscience 17 26%
Agricultural and Biological Sciences 5 8%
Medicine and Dentistry 3 5%
Psychology 1 2%
Other 2 3%
Unknown 8 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2021.
All research outputs
#968,785
of 17,522,501 outputs
Outputs from Acta Neuropathologica Communications
#70
of 1,072 outputs
Outputs of similar age
#26,636
of 284,930 outputs
Outputs of similar age from Acta Neuropathologica Communications
#1
of 1 outputs
Altmetric has tracked 17,522,501 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,072 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,930 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them