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Evolving evidence implicates cytomegalovirus as a promoter of malignant glioma pathogenesis

Overview of attention for article published in Herpesviridae, October 2011
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)

Mentioned by

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2 tweeters
googleplus
1 Google+ user

Citations

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42 Dimensions

Readers on

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74 Mendeley
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Title
Evolving evidence implicates cytomegalovirus as a promoter of malignant glioma pathogenesis
Published in
Herpesviridae, October 2011
DOI 10.1186/2042-4280-2-10
Pubmed ID
Authors

Charles S Cobbs, Charles S Cobbs

Abstract

Human cytomegalovirus (HCMV) was first reported to be strongly associated with human malignant gliomas in 2002. HCMV is a herpesvirus that causes congenital brain infection and multi-organ disease in immumocompromised individuals. Malignant gliomas are the most common and aggressive adult brain tumors and glioblastoma multiforme (GBM), the highest grade glioma, is associated with a life expectancy of less than two years. HCMV gene products encode for multiple proteins that can promote the various signaling pathways critical to tumor growth, including those involved in mitogenesis, mutagenesis, apoptosis, inflammation, angiogenesis, invasion and immuno-evasion. Several groups have now demonstrated that human malignant gliomas are universally infected with HCMV and express gene products that can promote key signaling pathways in glioma pathogenesis. In this review I discuss specific HCMV gene products that we and others have recently found to be expressed in GBM in vivo, including the HCMV IE1, US28, gB and IL-10 proteins. The roles these HCMV gene products play in dysregulating key pathways in glioma biology, including the PDGFR, AKT, STAT3, and monocyte/microglia function are discussed. Finally, I review emerging human clinical trials for GBM based on anti-HCMV strategies.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 3%
Unknown 72 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 15 20%
Researcher 13 18%
Student > Bachelor 12 16%
Student > Ph. D. Student 10 14%
Student > Doctoral Student 5 7%
Other 14 19%
Unknown 5 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 28%
Medicine and Dentistry 18 24%
Biochemistry, Genetics and Molecular Biology 13 18%
Chemistry 4 5%
Immunology and Microbiology 4 5%
Other 7 9%
Unknown 7 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2014.
All research outputs
#1,628,911
of 4,216,710 outputs
Outputs from Herpesviridae
#5
of 14 outputs
Outputs of similar age
#56,455
of 228,343 outputs
Outputs of similar age from Herpesviridae
#1
of 1 outputs
Altmetric has tracked 4,216,710 research outputs across all sources so far. This one has received more attention than most of these and is in the 60th percentile.
So far Altmetric has tracked 14 research outputs from this source. They receive a mean Attention Score of 2.1. This one scored the same or higher as 9 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,343 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them