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Relationships between mitochondrial content and bioenergetics with obesity, body composition and fat distribution in healthy older adults

Overview of attention for article published in BMC Obesity, October 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)

Mentioned by

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4 tweeters

Citations

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23 Dimensions

Readers on

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45 Mendeley
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Title
Relationships between mitochondrial content and bioenergetics with obesity, body composition and fat distribution in healthy older adults
Published in
BMC Obesity, October 2015
DOI 10.1186/s40608-015-0070-4
Pubmed ID
Authors

Manish S. Bharadwaj, Daniel J. Tyrrell, Iris Leng, Jamehl L. Demons, Mary F. Lyles, J. Jeffrey Carr, Barbara J. Nicklas, Anthony J. A. Molina

Abstract

Mitochondrial function declines with age; however, the relationship between adiposity and mitochondrial function among older adults is unclear. This study examined relationships between skeletal muscle mitochondrial content and electron transport chain complex 2 driven respiration with whole body and thigh composition, body fat distribution, and insulin sensitivity in older adults. 25 healthy, sedentary, weight-stable men (N = 13) and women (N = 12) >65 years of age, with a BMI range of 18-35 kg/m(2), participated in this study. Vastus lateralis biopsies were analyzed for citrate synthase (CS) activity and succinate mediated respiration of isolated mitochondria. Whole body and thigh composition were measured by DXA and CT. HOMA-IR was calculated using fasting glucose and insulin as an estimate of insulin sensitivity. Similar to reports in middle-aged adults, skeletal muscle CS activity was negatively correlated with BMI (R = -0.43) in our cohort of older adults. Higher total and thigh adiposity were correlated with lower CS activity independent of BMI (R = -0.50 and -0.71 respectively). Maximal complex 2 driven mitochondrial respiration was negatively correlated with lower body adiposity in males (R = -0.66). In this cohort of non-diabetic older adults, both HOMA-IR and insulin were positively correlated with CS activity when controlling for BMI (R = 0.57 and 0.66 respectively). Adiposity and body composition are correlated with skeletal muscle mitochondrial content and electron transport chain function in healthy, sedentary, community dwelling, older adults. Specific relationships of mitochondrial bioenergetics with gender and insulin sensitivity are also apparent. ClinicalTrials.gov identifier NCT01049698.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
Unknown 44 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 20%
Student > Ph. D. Student 7 16%
Student > Doctoral Student 5 11%
Researcher 4 9%
Professor > Associate Professor 3 7%
Other 6 13%
Unknown 11 24%
Readers by discipline Count As %
Medicine and Dentistry 8 18%
Biochemistry, Genetics and Molecular Biology 7 16%
Nursing and Health Professions 6 13%
Sports and Recreations 4 9%
Social Sciences 2 4%
Other 8 18%
Unknown 10 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2015.
All research outputs
#2,273,180
of 6,241,002 outputs
Outputs from BMC Obesity
#46
of 89 outputs
Outputs of similar age
#72,422
of 193,048 outputs
Outputs of similar age from BMC Obesity
#5
of 7 outputs
Altmetric has tracked 6,241,002 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 89 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 193,048 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.